T6397
3,3′,5-Triiodo-L-thyronine sodium salt
powder, BioReagent, suitable for cell culture
동의어(들):
Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T3
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H11I3NNaO4
CAS 번호:
Molecular Weight:
672.96
UNSPSC Code:
12352209
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-223-5
Beilstein/REAXYS Number:
8179867
MDL number:
Biological source:
synthetic
Form:
powder
Assay:
≥95%
InChI
1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
InChI key
SBXXSUDPJJJJLC-YDALLXLXSA-M
SMILES string
[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
biological source
synthetic
product line
BioReagent
assay
≥95%
form
powder
potency
0.02-50 ng/mL (lit.)
technique(s)
cell culture | mammalian: suitable
solubility
ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
human ... THRA(7067), THRB(7068)
rat ... Thra(81812), Thrb(24831)
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Application
3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.
Biochem/physiol Actions
3,3′,5′-Triiodo-L-thyronine (T3) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.
General description
3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.
Physical form
powder-20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days
Preparation Note
To prepare 20 μg/ml stock solution: add 1ml 1N NaOH per mg 3,3′, 5-triiodo-L-thyronine; gently swirl to dissolve. To this, add 49 ml sterile medium per ml 1N NaOH added.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Medical Biochemistry, 769-769 (2001)
Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha
Neumann H, et al.
The Journal of Experimental Medicine, 185(2), 305-316 (1997)
Hormones Growth Factors & Oncogenes, 219-219 (1987)
Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1
Sussman MA, et al.
The Journal of Clinical Investigation, 105(7), 875-886 (2000)
Iván Fernández-Lamo et al.
The European journal of neuroscience, 30(4), 679-692 (2009-08-19)
Activity-dependent changes taking place at the hippocampal perforant pathway-dentate gyrus synapse during classical eyeblink conditioning were recorded in adult thyroidectomized (hypothyroid) and control (euthyroid) rats, and in animals treated with thyroid hormones 20 days after thyroidectomy (recovery rats). The aim
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