V116
Z-VAD-FMK
≥98% (TLC), solid, Caspase inhibitor
동의어(들):
N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C22H30FN3O7
CAS 번호:
Molecular Weight:
467.49
UNSPSC Code:
12352209
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
solid
제품 이름
Z-VAD-FMK, solid
biological source
synthetic
Quality Segment
assay
≥98% (TLC)
form
solid
color
white
solubility
DMSO: 20 mg/mL, H2O: insoluble
storage temp.
−20°C
SMILES string
FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC
InChI
1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
InChI key
MIFGOLAMNLSLGH-QOKNQOGYSA-N
Gene Information
human ... CASP3(836)
mouse ... CASP3(12367)
rat ... CASP3(25402)
General description
Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase). It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.
Application
Z-VAD-FMK has been used:
- to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells
- to induce autophagy in Jurkat and K562 cells
- to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines
- as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53
Biochem/physiol Actions
Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Disclaimer
Hygroscopic
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저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)