V116

Z-VAD-FMK

Name: Z-VAD-FMK
Brand: SIGMA

≥98% (TLC), solid, Caspase inhibitor

동의어(들):

N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₂H₃₀FN₃O₇

CAS 번호:

187389-52-2

Molecular Weight:

467.49

UNSPSC Code:

12352209

NACRES:

NA.77

MDL number:

MFCD01074990

Assay:

≥98% (TLC)

Form:

solid

Quality level:

200

주요 문서

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도움 문의

제품 이름

Z-VAD-FMK, solid

biological source

synthetic

Quality Level

200

assay

≥98% (TLC)

form

solid

color

white

solubility

DMSO: 20 mg/mL, H₂O: insoluble

storage temp.

−20°C

SMILES string

FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC

InChI

1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1

InChI key

MIFGOLAMNLSLGH-QOKNQOGYSA-N

Gene Information

human ... CASP3(836)
mouse ... CASP3(12367)
rat ... CASP3(25402)

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General description

Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase). It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.

Application

Z-VAD-FMK has been used:

to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells
to induce autophagy in Jurkat and K562 cells
to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines
as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53

Biochem/physiol Actions

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Disclaimer

Hygroscopic

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 문서 section.

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

z-VAD-fmk inhibits peptide: N-glycanase and may result in ER stress

Misaghi S, et al.

Cell Death and Differentiation, 13(1), 163-163 (2006)

Increasing colorectal cancer cell sensitivity to oxaliplatin through hyperthermia and chloroquine treatment

Zheng C, et al.

International Journal of Clinical and Experimental Pathology, 9(2), 496-508 (2016)

Apoptosis inhibition can be threatening in Abeta-induced neuroinflammation, through promoting cell proliferation

Abdi A, et al.

Neurochemical Research, 36(1), 39-48 (2011)

Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation.

Peng Chen et al.

Theranostics, 10(11), 5107-5119 (2020-04-21)

Background and Purpose: RAS mutations limit the effectiveness of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies in combination with chemotherapy for metastatic colorectal cancer (mCRC) patients. Therefore, new cell death forms have focused on identifying indirect targets to inhibit Ras-induced

Deletion of Ripk3 prevents Motor Neuron death in vitro but not in vivo

Dermentzaki G, et al.

eNeuro, ENEURO-EN0308 (2019)

모든 관련된 서류 보기

문서

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

세포 주기 연구를 위한 생체 활성 저분자

증식하는 세포에서 세포 주기는 4단계로 구성됩니다. Gap 1(G1)은 유사분열과 세포 성장을 특징으로 하는 DNA 복제 사이의 기간입니다. DNA 복제는 합성(S)기에 일어나며, 세포 분열을 위한 성장 및 준비를 하는 Gap 2(G2)가 뒤따릅니다. 이 세 단계는 함께 세포주기의 간기 단계를 구성합니다. 간기 이후에 분열(M)기가 뒤따릅니다.

Z-VAD-FMK

≥98% (TLC), solid, Caspase inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

biological source

Quality Level

assay

form

color

solubility

storage temp.

SMILES string

InChI

InChI key

Gene Information

관련 카테고리

설명

General description

Application

Biochem/physiol Actions

Features and Benefits

Packaging

Disclaimer

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

시험 성적서(COA)

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