902659
Amino-PEG6-t-butyl ester
Synonym(s):
tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate, H2N-PEG6-CH2CH2COOtBu
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About This Item
Empirical Formula (Hill Notation):
C19H39NO8
CAS Number:
Molecular Weight:
409.51
UNSPSC Code:
51171641
NACRES:
NA.22
MDL number:
Form:
liquid
form
liquid
reaction suitability
reagent type: cross-linking reagent
refractive index
n/D 1.4562
density
1.06581 g/mL
functional group
amine, ester
storage temp.
−20°C
SMILES string
NCCOCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O
InChI
1S/C19H39NO8/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h4-17,20H2,1-3H3
InChI key
QGSFECNPSLZGGT-UHFFFAOYSA-N
Application
This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
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Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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