902667
Propargyl-PEG6-acid
Synonym(s):
4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid, Propargyl-PEG6-CH2CO2H
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About This Item
Empirical Formula (Hill Notation):
C16H28O8
CAS Number:
Molecular Weight:
348.39
UNSPSC Code:
12352106
NACRES:
NA.22
MDL number:
assay
≥95%
form
liquid
reaction suitability
reaction type: click chemistry, reagent type: cross-linking reagent
refractive index
n/D 1.469
functional group
alkyne, carboxylic acid
storage temp.
−20°C
SMILES string
OC(CCOCCOCCOCCOCCOCCOCC#C)=O
InChI
1S/C16H28O8/c1-2-4-19-6-8-21-10-12-23-14-15-24-13-11-22-9-7-20-5-3-16(17)18/h1H,3-15H2,(H,17,18)
InChI key
XRSJYQQOJNYUDV-UHFFFAOYSA-N
Application
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophilic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
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Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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