902683
BocNH-PEG5-acid
Synonym(s):
2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid, Boc-NH-PEG5-CH2COOH
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About This Item
Empirical Formula (Hill Notation):
C17H33NO9
CAS Number:
Molecular Weight:
395.45
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22
Form:
liquid
form
liquid
reaction suitability
reaction type: Pegylations, reagent type: cross-linking reagent
functional group
Boc, amine, carboxylic acid
storage temp.
−20°C
SMILES string
OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
InChI
1S/C17H33NO9/c1-17(2,3)27-16(21)18-4-5-22-6-7-23-8-9-24-10-11-25-12-13-26-14-15(19)20/h4-14H2,1-3H3,(H,18,21)(H,19,20)
InChI key
OLLNIAGWMCSEJB-UHFFFAOYSA-N
Application
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
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Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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