910023
3,6,9,12,15,18-Hexaoxahexacos-25-ynoic acid
Synonym(s):
2-2-2-2-2-2-6 PROTAC® linker, Alkyne-PEG6-acid, Bifunctional linker
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About This Item
Empirical Formula (Hill Notation):
C20H36O8
Molecular Weight:
404.50
UNSPSC Code:
12352106
Form:
liquid
form
liquid
reaction suitability
reagent type: linker
functional group
alkyne, carboxylic acid
storage temp.
2-8°C
SMILES string
OC(COCCOCCOCCOCCOCCOCCCCCCC#C)=O
Application
This heterobifunctional, PEGylated crosslinker 3,6,9,12,15,18-hexaoxahexacos-25-ynoic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG6-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation where the linker region is referred to as 2-2-2-2-2-2-6.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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