A0835
N-Acetyl-Asp-Glu-Val-Asp-al
≥95%, powder
Synonym(s):
Ac-DEVD-CHO
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About This Item
Empirical Formula (Hill Notation):
C20H30N4O11
CAS Number:
Molecular Weight:
502.47
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
biological source
synthetic
Quality Segment
assay
≥95%
form
powder
color
white
solubility
H2O: 1 mg/mL
storage temp.
−20°C
SMILES string
[H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C
InChI
1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)
InChI key
UMBVAPCONCILTL-UHFFFAOYSA-N
Gene Information
human ... CASP1(834), CASP3(836), CASP7(840), CASP8(841)
General description
N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) is a tetrapeptide with N-terminal acetylation and C-terminal aldehyde conjugation.
Application
N-Acetyl-Asp-Glu-Val-Asp-al has been used as a caspase inhibitor in muscle samples, smooth muscle cells and Jurkat T-cells.
Biochem/physiol Actions
N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) aids in the recovery of stunned myocardium by its caspase inhibition functionality.
Reversible inhibitor of IL-1β converting enzyme (ICE); inhibits poly(ADP-ribose) polymerase cleavage by apopain (caspase 3).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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