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211370

Sulfamide

Name: Sulfamide
Brand: ALDRICH

99%

Synonym(s):

Imidosulfamic acid, Sulfamoylamine, Sulfonyl diamide, Sulfuryl amide, Sulfuryl diamide

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About This Item

Linear Formula:

(NH₂)₂SO₂

CAS Number:

7803-58-9

Molecular Weight:

96.11

NACRES:

NA.22

PubChem Substance ID:

24852683

UNSPSC Code:

12352100

EC Number:

232-262-9

MDL number:

MFCD00011606

Assay:

99%

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Properties

Quality Level

200

assay

99%

mp

90-92 °C (lit.)

solubility

water: soluble 50 mg/mL, clear, colorless to faintly yellow

density

1.611 g/mL at 25 °C (lit.)

SMILES string

NS(N)(=O)=O

InChI

1S/H4N2O2S/c1-5(2,3)4/h(H4,1,2,3,4)

InChI key

NVBFHJWHLNUMCV-UHFFFAOYSA-N

Gene Information

human ... CA1(759), CA2(760)

Description

General description

Sulfamide, a polar aprotic solvent compatible with Grignard reagents, is used as a functional group in medicinal chemistry.

Application

Sulfamide was used in the synthesis of:

Schiff bases of the type ArCH=NSO₂NH₂
1H,3H-2,1,3-benzothiadiazin-4-one-2,2-dioxide (BTDD)
sulfamide analogs of oleoylethanolamide analogs in a study of PPARα activation.

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.

Anna Di Fiore et al.

Bioorganic & medicinal chemistry letters, 20(12), 3601-3605 (2010-05-18)

We investigated the inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms I-XV with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylsulfamide and other simple or sugar sulfamides, a class of less investigated CA inhibitors (CAIs). The crystal structure of the adduct of hCA II with the boron-substituted

Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV by sulfamide and sulfamic acid derivatives.

A Scozzafava et al.

Journal of enzyme inhibition, 15(5), 443-453 (2000-10-13)

Sulfamide and sulfamic acid are the simplest compounds containing the SO2NH2 moiety, responsible for binding to the Zn(II) ion within carbonic anhydrase (CA, EC 4.2.1.1) active site, and thus acting as inhibitors of the many CA isozymes presently known. Here

Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPARalpha activation.

Carolina Cano et al.

Journal of medicinal chemistry, 50(2), 389-393 (2007-01-19)

Long chain saturated and unsaturated alkyl sulfamide and propyl sulfamide derivatives, analogs of oleoylethanolamide, have been synthesized and evaluated in vivo and in vitro as peroxisome proliferator activated receptor alpha (PPARalpha) activators. Additionally, the anorexic effects of the new compounds

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