281778
(3-Aminopropyl)trimethoxysilane
97%
Synonym(s):
3-(Trimethoxysilyl)propylamine
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About This Item
Linear Formula:
H2N(CH2)3Si(OCH3)3
CAS Number:
Molecular Weight:
179.29
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
EC Number:
237-511-5
Beilstein/REAXYS Number:
2038118
MDL number:
Quality Level
InChI key
SJECZPVISLOESU-UHFFFAOYSA-N
InChI
1S/C6H17NO3Si/c1-8-11(9-2,10-3)6-4-5-7/h4-7H2,1-3H3
SMILES string
CO[Si](CCCN)(OC)OC
assay
97%
form
liquid
bp
91-92 °C/15 mmHg (lit.)
density
1.027 g/mL at 25 °C (lit.)
General description
(3-Aminopropyl)trimethoxysilane (APTMS) is a high-reactivity aminosilane engineered for the deposition of cationic Self-Assembled Monolayers (SAMs) on inorganic substrates. Its trimethoxy structure ensures faster hydrolysis and denser surface grafting compared to ethoxy-silanes, providing a terminal primary amine (-NH2) handle for the covalent attachment of biomolecules, polymers, and fluorophores. Beyond biotechnology, APTMS is a pivotal interfacial modifier in nanoelectronics, where it passivates dielectric surfaces to enhance charge-carrier mobility in organic field-effect transistors (OFETs) and enables the precise alignment of carbon nanotubes and graphene. Refined to a 99% high-purity specification, this grade is engineered to provide excellent consistency for applications requiring precise and reliable surface functionalization.
Application
As a versatile molecular bridge, APTMS is essential for engineering intelligent interfaces and stimuli-responsive systems that enable precise interactions at the intersection of nanotechnology, biology, and electronics.
Stimuli-Responsive Nanocarriers: Functionalizes mesoporous silica pores to create pH-sensitive "gatekeepers" that trigger drug release specifically within acidic tumor microenvironments.
Gene & Nucleic Acid Delivery: Modulates the surface zeta potential of nanoparticles to facilitate high-efficiency electrostatic loading and endosomal escape of siRNA, mRNA, and pDNA.
Precision Bioconjugation: Acts as a molecular bridge for anchoring targeting ligands (e.g., Folate, RGD peptides) or PEG chains to gold and iron oxide nanoparticles for enhanced circulation and cell-specific uptake.
Advanced Biosensing: Utilized in LSPR-based diagnostics to immobilize antibodies onto gold nanostructures, enabling real-time detection of clinical biomarkers such as C-reactive protein (CRP).
Neuro-Targeting: Recent findings highlight its role in tuning nanoparticle surface charge to improve Blood-Brain Barrier (BBB) permeability via adsorptive-mediated transcytosis
Stimuli-Responsive Nanocarriers: Functionalizes mesoporous silica pores to create pH-sensitive "gatekeepers" that trigger drug release specifically within acidic tumor microenvironments.
Gene & Nucleic Acid Delivery: Modulates the surface zeta potential of nanoparticles to facilitate high-efficiency electrostatic loading and endosomal escape of siRNA, mRNA, and pDNA.
Precision Bioconjugation: Acts as a molecular bridge for anchoring targeting ligands (e.g., Folate, RGD peptides) or PEG chains to gold and iron oxide nanoparticles for enhanced circulation and cell-specific uptake.
Advanced Biosensing: Utilized in LSPR-based diagnostics to immobilize antibodies onto gold nanostructures, enabling real-time detection of clinical biomarkers such as C-reactive protein (CRP).
Neuro-Targeting: Recent findings highlight its role in tuning nanoparticle surface charge to improve Blood-Brain Barrier (BBB) permeability via adsorptive-mediated transcytosis
Packaging
Optically tunable core-shell composite nanorod structures have been prepared by depositing gold onto silica and titania nanorods which have been surface modified with (3-Aminopropyl)trimethoxysilane
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2
Storage Class
10 - Combustible liquids
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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Fundamental Aspects of Electrochemical Deposition and Dissolution (2000)
Elza D van Deel et al.
The Journal of physiology, 595(14), 4597-4610 (2017-05-10)
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International Conference on Nano-Bio Sensing, Imaging, and Spectroscopy 2017, 10324(12), 103240E-103240E (2017)
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We have recently demonstrated that vertically aligned gold nanowires (v-AuNWs) are outstanding material candidates for wearable biomedical sensors toward real-time and noninvasive health monitoring because of their excellent tunable electrical conductivity, biocompatibility, chemical inertness, and wide electrochemical window. Here, we
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