F5396
Fenbendazole
≥98%
Synonym(s):
Methyl 5-(phenylthio)-2-benzimidazolecarbamate
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About This Item
Empirical Formula (Hill Notation):
C15H13N3O2S
CAS Number:
Molecular Weight:
299.35
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
256-145-7
Beilstein/REAXYS Number:
759077
MDL number:
Assay:
≥98%
Quality Level
assay
≥98%
SMILES string
COC(=O)Nc1nc2cc(Sc3ccccc3)ccc2[nH]1
InChI
1S/C15H13N3O2S/c1-20-15(19)18-14-16-12-8-7-11(9-13(12)17-14)21-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)
InChI key
HDDSHPAODJUKPD-UHFFFAOYSA-N
General description
Fenbendazole also known as Methyl 5-(phenylthio)-2-benzimidazolecarbamate, is a benzimidazole anthelmintic and antiprotozoal agent.
Application
- Fenbendazole in Veterinary Medicine: Investigated for efficacy against coccidicidal fungi in avian species, demonstrating broad-spectrum antiparasitic potential. Additionally, its environmental impact and pharmacokinetics reveal insights for sustainable agricultural practices and disease vector control. (Lozano et al., 2024), (Hachgenei et al., 2024), (Durden et al., 2023).
- Food safety and allergen detection: Fenbendazole′s implications in food safety are explored through quantitative PCR methods for detecting allergenic species in foods, underscoring the importance of accurate detection techniques in food industry compliance and safety standards (Costa et al., 2023).
- Analysis of antibiotic and anthelmintic residues: The occurrence and exposure evaluation of Fenbendazole residues in cow milk in China is studied, emphasizing the need for rigorous monitoring of food products to ensure public health safety (Chang et al., 2023).
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2
target_organs
Liver,lymph node,Stomach,Nervous system
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
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Penny K Patten et al.
Veterinary clinical pathology, 42(1), 103-108 (2013-01-03)
Mesocestoides cestode infections in dogs are well known for causing severe peritonitis with larvae or larval fragments (metacestodes, tetrathyridia, or calcareous corpuscles) frequently observed cytologically in peritoneal fluid samples. This case report describes the cytologic and clinical features of 2
C Chassaing et al.
Journal of medicinal chemistry, 51(5), 1111-1114 (2008-02-15)
Highly water-soluble prodrugs 1a- g of anthelmintic benzimidazole carbamates 2a- g were synthesized. These prodrugs combine high aqueous solubility and stability with high lability in the presence of alkaline phosphatases. The veterinary utility of 1a was shown by a pharmacodynamic
Nilambra Dogra et al.
The Journal of biological chemistry, 287(36), 30625-30640 (2012-06-30)
In recent years, there has been a great deal of interest in proteasome inhibitors as a novel class of anticancer drugs. We report that fenbendazole (FZ) (methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate) exhibits a potent growth-inhibitory activity against cancer cell lines but not normal