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Merck

W318000

2-Mercaptopropionic acid

≥95%, FG

Synonym(s):

Thiolactic acid, 2-Mercaptopropionic acid

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About This Item

Linear Formula:
CH3CH(SH)COOH
CAS Number:
Molecular Weight:
106.14
FEMA Number:
3180
Council of Europe no.:
4156
UNSPSC Code:
12164502
PubChem Substance ID:
NACRES:
NA.21
EC Number:
201-206-5
Flavis number:
12.039
MDL number:
Beilstein/REAXYS Number:
506218
Organoleptic:
meaty; roasted; sulfurous
Grade:
FG, Fragrance grade, Halal, Kosher
Biological source:
synthetic
Agency:
follows IFRA guidelines, meets purity specifications of JECFA
Food allergen:
no known allergens
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biological source

synthetic

Quality Level

grade

FG, Fragrance grade, Halal, Kosher

agency

follows IFRA guidelines, meets purity specifications of JECFA

reg. compliance

EU Regulation 1223/2009, EU Regulation 1334/2008 & 872/2012

assay

≥95%

refractive index

n20/D 1.481 (lit.)

bp

102 °C/16 mmHg (lit.), 203-208 °C (lit.)

mp

10-14 °C (lit.)

density

1.196 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

fragrance allergen

no known allergens

organoleptic

meaty; roasted; sulfurous

SMILES string

CC(S)C(O)=O

InChI

1S/C3H6O2S/c1-2(6)3(4)5/h2,6H,1H3,(H,4,5)

InChI key

PMNLUUOXGOOLSP-UHFFFAOYSA-N

General description

2-Mercaptopropionic acid is a synthetic flavor and skin sensitizer used in cosmetics, food and household care products.

Application

  • Improving the Efficacy of ALA-Based Photodynamic Therapy: 2-MPA was used in the one-step aqueous synthesis of anionic and cationic AgInS2 quantum dots, demonstrating a significant enhancement in the therapeutic efficacy of aminolevulinic acid-based photodynamic cancer therapy (Hashemkhani et al., 2022).

  • Fabrication of Hierarchical Core-Shell Heteroarchitectures: 2-MPA facilitates the assembly of Au@ZnO heterostructures for photocatalytic applications, underscoring its pivotal role in the synthesis of complex nanostructured materials (Pączkowski & Gawdzik, 2021).

  • Investigating Genotoxic and Apoptotic Pathways: This study uses 2-MPA coated silver sulfide quantum dots to explore their effects on genotoxic and apoptotic pathways in vitro, providing insights into the biocompatibility and safety profile of these nanomaterials (Ozkan Vardar et al., 2018).


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signalword

Danger

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

190.4 °F - closed cup

flash_point_c

88 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

pictograms

CorrosionExclamation mark

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1A



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RIFM fragrance ingredient safety assessment, 2-mercaptopropionic acid, CAS Registry Number 79-42-5
Api AM, et al.
Food And Chemical Toxicology, 111987-111987 (2021)
Lu Lai et al.
Journal of colloid and interface science, 389(1), 61-70 (2012-10-10)
The toxicity of CdTe QDs modified with three different ligands, namely mercaptopropionic acid (MPA), N-acetyl-L-cysteine (NAC), and glutathione (GSH), were investigated via microcalorimetric, spectroscopic, and microscopic methods. The three ligand-modified QDs have nearly identical hydrodynamic size. The results of the
L Chen et al.
Journal of medicinal chemistry, 40(6), 864-876 (1997-03-14)
Using as models the neurohypophyseal nonapeptide hormone oxytocin and its analogue deaminooxytocin, several directed routes to formation of sulfur-sulfur bridges have been developed and evaluated. The linear sequences (through common octapeptide-resin intermediates) were assembled smoothly on tris(alkoxy)benzylamide (PAL) poly(ethylene glycol)-polystyrene