Heat Shock Protein Inhibitor I

Name: Heat Shock Protein Inhibitor I
Brand: MM

Heat Shock Protein Inhibitor I, CAS 218924-25-5 blocks the induction of HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner.

Synonym(s):

Heat Shock Protein Inhibitor I, KNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₁NO₄

CAS Number:

218924-25-5

Molecular Weight:

245.23

MDL number:

MFCD24369049

UNSPSC Code:

12352202

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

OK to freeze, protect from light

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InChI key

LZGGUFLRKIMBDQ-UHFFFAOYSA-N

SMILES string

N1(CCC(=Cc2cc3c(cc2)OCO3)C1=O)C=O

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white to light yellow

solubility

DMSO: 3 mg/mL, olive oil: soluble

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no

Primary Target
Hsp70

Product does not compete with ATP.

Reversible: no

Disclaimer

Toxicity: Harmful (C)

General description

A benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK.

A benzylidine lactam compound that inhibits the induction of heat shock proteins, including HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner, but does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600), and, unlike quercetin, it does not affect the activities of PKA, PKC, and PTK.

Other Notes

Koishi, M., et al. 2001. Clin. Cancer Res.7, 215.
Yokota, S., et al. 2000. Cancer Res.60, 2942.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Heat Shock Protein Inhibitor I