5.43899
NMP
for liquid chromatography LiChrosolv®
Synonym(s):
1-Methyl-2-pyrrolidone, NMP, N-Methyl-2-pyrrolidone
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About This Item
Product Name
1-Methyl-2-pyrrolidone, for liquid chromatography LiChrosolv®
vapor pressure
0.32 hPa ( 20 °C)
Quality Level
description
isocratic
product line
LiChrosolv®
assay
≥99.5% (GC)
form
liquid
autoignition temp.
245 °C
expl. lim.
1.3-9.5 % (v/v)
technique(s)
HPLC: suitable
impurities
≤0.05% Water
transmittance
300 nm, ≥50%, 325 nm, ≥90%, 350 nm, ≥97%, 400 nm, ≥99%
pH
8.5-10.0 (20 °C, 100 g/L in H2O)
bp
202 °C/1013 hPa
mp
-24 °C
transition temp
flash point 91 °C
solubility
1000 g/L
density
1.03 g/cm3 at 20 °C
storage temp.
2-30°C
SMILES string
N1(CCCC1=O)C
InChI
1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
InChI key
SECXISVLQFMRJM-UHFFFAOYSA-N
Application
- Novel transdermal bioadhesive surfactant-based system for release and solubility improvement of antimalarial drugs artemether-lumefantrine: This study utilizes 1-Methyl-2-pyrrolidone (NMP) as a high-purity solvent in the formulation of a transdermal bioadhesive system, enhancing the solubility and delivery of antimalarial drugs. The application highlights NMP′s role in pharmaceutical formulations, particularly in improving drug efficacy and patient compliance (Volpe-Zanutto et al., 2021).
Analysis Note
Water: ≤ 0.05 %
Transmission (at 300 nm): ≥ 50 %
Transmission (at 325 nm): ≥ 90 %
Transmission (at 350 nm): ≥ 97 %
Transmission (at 400 nm): ≥ 99 %
Other Notes
Legal Information
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signalword
Danger
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
195.8 °F - Pensky-Martens closed cup
flash_point_c
91 °C - Pensky-Martens closed cup
Certificates of Analysis (COA)
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