I0759
Anti-Human IgM (μ-chain specific) antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti Human IgM Antibody - Anti-Human IgM (μ-chain specific) antibody produced in goat, Anti Human Igm, Anti Human Igm Antibody, Anti-Human Igm
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ODD, QPA
Citations:
20
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
secondary antibodies
clone
polyclonal
form
lyophilized powder
technique(s)
Ouchterlony double diffusion: suitable, quantitative precipitin assay: suitable
storage temp.
2-8°C
target post-translational modification
unmodified
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General description
Human serum-derived IgM may be used as a reference antigen, standard, blocking agent, or coating protein in a variety of immunoassays including ELISA, dot immunobinding, Western immunoblotting, immunodiffusion, and immunoelectrophoresis. Other applications include starting materials for the preparation of immunogens and solid phase immunoadsorbents.
Immunoglobulin M (IgM) antibodies appear early in the course of infections. IgM antibodies are responsible for agglutination of red blood cells in mis-matched blood transfusions. The level of IgM may vary with the status of disease or infection.
Immunoglobulin M (IgM) antibodies appear early in the course of infections. IgM antibodies are responsible for agglutination of red blood cells in mis-matched blood transfusions. The level of IgM may vary with the status of disease or infection.
IgM antibodies are present as pentamers in the serum and are produced in response to antigens
Anti-Human IgM (μ-chain specific) antibody is specific for human IgM with mu chain. The antibody preparation is specific for human IgM when tested against purified human IgA, IgG, IgM, Bence Jones κ and Bence Jones λ myeloma proteins.
Anti-Human IgM (μ-chain specific) antibody is specific for human IgM with mu chain. The antibody preparation is specific for human IgM when tested against purified human IgA, IgG, IgM, Bence Jones κ and Bence Jones λ myeloma proteins.
Immunogen
Purified human IgM as immunogen
Application
Anti-Human IgM (μ-chain specific) antibody is suitable for Ouchterlony double diffusion and quantitative precipitin assay. It was used in B-cell receptor cross-linking studies, AuBioDOT assays, ELISA, protein purification and gel blot analysis.
Goat polyclonal Anti-Human IgM (μ-chain specific) antibody may be used to identify and quantitate the level of human IgM in vitro and in human serum or other biological fluids by immunochemical or immunohistological techniques.
Biochem/physiol Actions
Goat polyclonal Anti-Human IgM (μ-chain specific) antibody reacts with the m-chain of human IgM. It is specific for human IgM when tested against purified human IgA, IgG, IgM, Bence Jones kappa and Bence Jones lambda myeloma proteins.
Physical form
Lyophilized from 0.01 M sodium phosphate, 0.015 M sodium chloride, pH 7.2
Preparation Note
Reconstitute with 0.135 M sodium chloride.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Tulika Singh et al.
PLoS neglected tropical diseases, 13(8), e0007648-e0007648 (2019-08-27)
Zika virus (ZIKV) is a newly-identified infectious cause of congenital disease. Transplacental transfer of maternal IgG to the fetus plays an important role in preventing many neonatal infections. However, antibody transfer may also have negative consequences, such as mediating enhancement
Zhen Lin et al.
Journal of virology, 90(7), 3469-3479 (2016-01-15)
In the oral epithelium, peripheral stores of Epstein-Barr virus (EBV) are transmitted from infiltrating B cells to epithelial cells. Once the virus is transmitted to epithelial cells, the highly permissive nature of this cell type for lytic replication allows virus
Susana Vázquez et al.
Clinical and diagnostic laboratory immunology, 10(6), 1074-1077 (2003-11-11)
The Dengue IgM Capture ELISA (MAC-ELISA) is the immunoenzymatic system recommended by the Pan American Health Organization and the World Health Organization for the serological diagnosis of dengue virus infection due to its high sensitivity, ease of performance, and use
Tina O'Grady et al.
Nucleic acids research, 44(18), e145-e145 (2016-07-14)
Annotation of herpesvirus genomes has traditionally been undertaken through the detection of open reading frames and other genomic motifs, supplemented with sequencing of individual cDNAs. Second generation sequencing and high-density microarray studies have revealed vastly greater herpesvirus transcriptome complexity than
Whitney Bullard et al.
Virulence, 3(1), 72-76 (2012-01-31)
The haptoglobin-hemoglobin receptor (HpHbR) of African trypanosomes plays a critical role in human innate immunity against these parasites. Localized to the flagellar pocket of the veterinary pathogen Trypanosoma brucei brucei this receptor binds Trypanosome Lytic Factor-1 (TLF-1), a subclass of
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