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P2607

PRE-084

Name: PRE-084
Brand: SIGMA

σ1 opioid receptor agonist, solid

Synonym(s):

2-(4-morpholinethyl)-1-phenylcyclohexanecarboxylate hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₇NO₃ · HCl

Molecular Weight:

353.88

UNSPSC Code:

12352200

PubChem Substance ID:

24278627

NACRES:

NA.77

MDL number:

MFCD00673883

Form:

solid

Quality level:

200

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Properties

Product Name

PRE-084, solid

description

Drug Control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet.

Quality Level

200

form

solid

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

solubility

H₂O: ≤24 mg/mL

SMILES string

Cl.O=C(OCCN1CCOCC1)C2(CCCCC2)c3ccccc3

InChI

1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H

InChI key

QUJWFJNHTBKCLU-UHFFFAOYSA-N

Gene Information

human ... OPRS1(10280)
rat ... Oprs1(29336), Slc6a3(24898)

Description

Biochem/physiol Actions

PRE-084 is a potent and highly selective σ1 opioid receptor agonist. It offers neuroprotection upon embolic stroke.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

070K4604

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The attenuation of learning impairments induced after exposure to CO or trimethyltin in mice by sigma (sigma) receptor ligands involves both sigma1 and sigma2 sites.

T Maurice et al.

British journal of pharmacology, 127(2), 335-342 (1999-06-29)

1. Sigma (sigma) receptor ligands were previously reported to alleviate learning and memory impairments on several pharmacological and pathological rodent models of amnesia. Such effect was demonstrated as involving the sigma1 subtype of sigma receptor. 2. In this study, we

Sigma-1 receptor activation inhibits osmotic swelling of rat retinal glial (Müller) cells by transactivation of glutamatergic and purinergic receptors.

Stefanie Vogler et al.

Neuroscience letters, 610, 13-18 (2015-10-27)

Water accumulation in retinal glial (Müller) and neuronal cells resulting in cellular swelling contributes to the development of retinal edema and neurodegeneration. Sigma (σ) receptor activation is known to have neuroprotective effects in the retina. Here, we show that the

Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats

Allahtavakoli M and Jarrott B

Brain Research Bulletin, 85(3-4), 219-224 (2011)

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