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P8761

Probenecid

Name: Probenecid
Brand: SIGMA

≥98% (NaOH, titration), powder, uricosuric agent

Synonym(s):

p-(Dipropylsulfamoyl)benzoic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₉NO₄S

CAS Number:

57-66-9

Molecular Weight:

285.36

NACRES:

NA.77

PubChem Substance ID:

24898976

UNSPSC Code:

12161501

EC Number:

200-344-3

MDL number:

MFCD00038402

Assay:

≥98% (NaOH, titration)

Quality level:

200

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Properties

Product Name

Probenecid,

assay

≥98% (NaOH, titration)

Quality Level

200

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

SMILES string

CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O

InChI

1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)

InChI key

DBABZHXKTCFAPX-UHFFFAOYSA-N

Gene Information

human ... SLC22A11(55867), SLC22A6(9356), SLC22A8(9376)

Description

Application

Probenecid has been used:

as a component of phenol red free Hank′s buffer for Intracellular Ca²⁺-mobilization assay
as a component of calcium sensitive dye for calcium mobilization Studies
as a supplement in Hank′s balanced salt solution (HBSS) assay buffer

Useful as an inhibitor of the organic anion transporter, MRP.

Biochem/physiol Actions

Probenecid is a uricosuric agent, which increases uric acid removal in the urine and reduces urate reuptake. It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout. Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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