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151270

1-(2-Pyridyl)piperazine

Name: 1-(2-Pyridyl)piperazine
Brand: ALDRICH

98%

Synonym(s):

2-Piperazinopyridine

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₃N₃

CAS Number:

34803-66-2

Molecular Weight:

163.22

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24849108

EC Number:

252-220-3

Beilstein/REAXYS Number:

140423

MDL number:

MFCD00006216

Assay:

98%

Form:

liquid

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Properties

Quality Level

200

assay

98%

form

liquid

refractive index

n20/D 1.595 (lit.)

bp

120-122 °C/2 mmHg (lit.)

density

1.072 g/mL at 25 °C (lit.)

SMILES string

C1CN(CCN1)c2ccccn2

InChI

1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2

InChI key

GZRKXKUVVPSREJ-UHFFFAOYSA-N

Description

Application

1-(2-Pyridyl)piperazine was used to determine the aliphatic and aromatic isocyanates in air.

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Determination of trace atmospheric isocyanate concentrations by reversed-phase high-performance liquid chromatography using 1-(2-pyridyl) piperazine reagent.

Journal of Chromatography A, 212(1), 93-104 (1981)

Pharmacological evidence for the involvement of 1-(2-pyridinyl)-piperazine (1-PmP) in the interaction of buspirone or gepirone with noradrenergic systems.

P Giral et al.

European journal of pharmacology, 134(1), 113-116 (1987-01-28)

We investigated in mice the effects of one of the principal metabolites of buspirone and gepirone, 1-(2-pyridinyl)-piperazine (1-PmP), on hypothermia and reduced locomotion induced by clonidine (0.25 and 0.06 mg/kg, respectively), tests related to brain alpha-adrenergic function. Both effects were

6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.

Harvey Wong et al.

Drug metabolism and disposition: the biological fate of chemicals, 35(8), 1387-1392 (2007-05-15)

The pharmacokinetics and in vivo potency of 6-hydroxybuspirone (6-OH-buspirone), a major metabolite of buspirone, were investigated. The plasma clearance (47.3 +/- 3.5 ml/min/kg), volume of distribution (2.6 +/- 0.3 l/kg), and half-life (1.2 +/- 0.2 h) of 6-OH-buspirone in rats

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