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Resomer® RG 502 H, Poly(D,L-lactide-co-glycolide)
acid terminated, viscosity 0.16-0.24 dL/g
Synonym(s):
PLGA
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About This Item
Linear Formula:
[C3H4O2]x[C2H2O2]y
CAS Number:
MDL number:
UNSPSC Code:
12162002
NACRES:
NA.23
Product Name
Resomer® RG 502 H, Poly(D,L-lactide-co-glycolide), acid terminated, viscosity 0.16-0.24 dL/g
SMILES string
O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O
InChI
1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2
InChI key
LCSKNASZPVZHEG-UHFFFAOYSA-N
form
amorphous
feed ratio
lactide:glycolide 50:50
degradation timeframe
<3 months
viscosity
0.16-0.24 dL/g
transition temp
Tg 42-46 °C
storage temp.
2-8°C
Quality Level
Related Categories
Application
Poly(D,L-lactide-co-glycolide) (PLGA) canbe used:
- In the formulation ofa non-aqueous drug delivery system for H2S donors to aid thesustained release of the drug.
- To prepare a polymer blend containing Ganciclovir-loaded microspheresdispersed in PLGA–PEG–PLGA polymer gel. This formulation can be used as asustained delivery system for Ganciclovir drug.
Legal Information
Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Diazeniumdiolate-doped poly (lactic-co-glycolic acid)-based nitric oxide releasing films as antibiofilm coatings.
Cai W,et al.
Biomaterials, 33(32), 7933-7944 (2012)
A Patil et al.
AAPS PharmSciTech, 18(6), 2291-2302 (2017-01-20)
Hydrogen sulfide (H2S) targets both underlying factors in glaucoma pathogenesis by reducing elevated intraocular pressure (IOP) and providing retinal neuroprotection, whereas the current clinical approaches targets only reducing IOP. Therefore, H2S could be a potential superior candidate for glaucoma pharmacotherapy.
Z Zhuang et al.
Journal of dental research, 98(2), 200-208 (2018-11-06)
Periodontitis is characterized by the progressive destruction of tooth-supporting alveolar bone, which is mainly caused by chronic inflammation in response to persistent bacterial insult. It has recently become clear that the pathogenesis of periodontitis is associated with a high ratio
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
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