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Merck

700184M

Avanti

desmosterol (D6) ester

Avanti Research™ - A Croda Brand

Synonym(s):

111014

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About This Item

Empirical Formula (Hill Notation):
C45H70D6O2
CAS Number:
2260669-31-4
Molecular Weight:
655.12
MDL number:
MFCD00133427
NACRES:
NA.12
UNSPSC Code:
12352211

Key Documents

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Product Name

desmosterol (D6) ester, 26,26,26,27,27,27-hexadeuteriocholesta-5,24-dien-3β-ol (9Z-octadecenoate), methylene chloride solution

assay

>99% (TLC)

form

methylene chloride solution

packaging

pkg of 1 × 1 mL (700184M-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 700184M

concentration

1 mg/mL (700184M-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

Desmosterol is a precursor of cholesterol synthesis and the enzyme 24-dehydrocholesterol reductase catalyzes this step. It lacks a double bond between C24 and C25, which is present in cholesterol. Desmosterol is the major brain sterol and is localized in spermatozoa membrane and astrocytes. Desmosterol (D6) ester is a deuterated desmosterol with octadecanoic acid.

Biochem/physiol Actions

Desmosterol is a liver X receptor (LXR) agonist and it regulates inflammatory signaling in macrophages. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. It is a potential therapeutic target for treating the neurodegenerative disorder.

Packaging

5 mL Clear Glass Sealed Ampule (700184M-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Central nervous system

wgk

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

75-09-2

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Saara Vainio et al.
The Journal of biological chemistry, 281(1), 348-355 (2005-10-27)
Desmosterol is an immediate precursor of cholesterol in the Bloch pathway of sterol synthesis and an abundant membrane lipid in specific cell types. The significance of the difference between the two sterols, an additional double bond at position C24 in

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