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Merck

800812P

Avanti

12:0 DG

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-didodecanoyl-sn-glycerol; DG(12:0/12:0/0:0); 110611

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About This Item

Empirical Formula (Hill Notation):
C27H52O5
CAS Number:
60562-15-4
Molecular Weight:
456.70
MDL number:
MFCD00067469
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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SMILES string

O([C@H](COC(=O)CCCCCCCCCCC)CO)C(=O)CCCCCCCCCCC

InChI

1S/C27H52O5/c1-3-5-7-9-11-13-15-17-19-21-26(29)31-24-25(23-28)32-27(30)22-20-18-16-14-12-10-8-6-4-2/h25,28H,3-24H2,1-2H3/t25-/m0/s1

InChI key

OQQOAWVKVDAJOI-VWLOTQADSA-N

description

1,2-dilauroyl-sn-glycerol

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (800812P-10mg), pkg of 1 × 200 mg (800812P-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

neutral glycerides
neutral lipids

shipped in

dry ice

storage temp.

−20°C

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General description

sn-1,2-diacylglycerols comprise short saturated acyl side chains (C4-C10) and 12:0 DG is also called 1,2-dilauroyl-sn-glycerol.

Application

12:0 DG has been used as an internal standard for spiking serum samples for liquid chromatography–mass spectrometry analysis. It may be used as an internal standard for spiking RAW 264.7 cells for mass spectroscopy studies and in reverse phase liquid chromatography coupled mass spectrometer for lipidomics studies of human plasma and serum samples.

Biochem/physiol Actions

1,2-dilauroyl-sn-glycerol is a polymerization initiator used in the synthesis of (R)-3-((2-bromo-2-methylpropanoyl)oxy)propane-1,2-diyl didodecanoate (BMPD). sn-1,2-diacylglycerols are prime regulators of biological functions especially in platelets. They also activate protein kinase C.

Packaging

5 mL Amber Glass Screw Cap Vial (800812P-10mg)
5 mL Amber Glass Screw Cap Vial (800812P-200mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Lipid Profile Characterization and Lipoprotein Comparison of Extracellular Vesicles from Human Plasma and Serum
Sun Y, et al.
Metabolites, 9(11), 259-259 (2019)
Felicitas S Boretti et al.
Metabolomics : Official journal of the Metabolomic Society, 16(1), 1-1 (2019-12-05)
Food and dietary ingredients have significant effects on metabolism and health. To evaluate whether and how different diets affected the serum lipidomic profile of dogs. Sixteen healthy beagles were fed a commercial dry diet for 3 months (control diet). After an
Serum lipidome analysis of healthy beagle dogs receiving different diets
Boretti FS, et al.
Metabolomics, 16(1), 1-1 (2020)
Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm
Callender HL, et al.
Analytical Chemistry, 79(1), 263-272 (2007)
Li Yang et al.
Analytical and bioanalytical chemistry, 412(10), 2225-2235 (2020-01-07)
A novel online two-dimensional supercritical fluid chromatography/reversed-phase liquid chromatography-triple-quadrupole mass spectrometry (2D SFC/RPLC-QQQ MS) method based on a vacuum solvent evaporation interface was developed for lipid profiling in human plasma, in which lipid classes were separated by the first-dimension SFC
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