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810207X

Avanti

NBD Sphingosine-1-Phosphate

Avanti Research™ - A Croda Brand

Synonym(s):

omega(7-nitro-2-1,3-benzoxadiazol-4-yl)-D-erythro-sphingosine-1-phosphate:methanol:water (65:25:4)

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About This Item

Empirical Formula (Hill Notation):
C24H40N5O8P
CAS Number:
799268-48-7
Molecular Weight:
557.58
MDL number:
MFCD00036835
NACRES:
NA.25
UNSPSC Code:
12352211
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Product Name

NBD Sphingosine-1-Phosphate, Avanti Research™ - A Croda Brand 810207X

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810207X-100ug), pkg of 1 × 1 mL (810207X-50ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810207X

concentration

0.05 mg/mL (810207X-50ug), 0.1 mg/mL (810207X-100ug)

shipped in

dry ice

storage temp.

−20°C

General description

Sphingosine-1-phosphate is a phosphorylated sphingosine analog and is polar. It is terminally labelled by fluorescent nitrobenzo-2-oxa-1,3-diazole (NBD) group. Sphingosine-1-phosphate is abundantly stored in platelets.

Application

NBD sphingosine-1-phosphate has been used as a substrate in the detection of sphingosine-1-phosphate phosphatases (SPPase) enzymatic activity by in vitro assay.

Biochem/physiol Actions

Sphingosine-1-phosphate (S1P) initiates DNA synthesis. It is also involved in cell division, cell growth and platelet activation. S1P mediates cell movement, differentiation and survival. It specifically stimulates endothelial cells.

Packaging

5 mL Amber Glass Screw Cap Vial (810207X-100ug)
5 mL Amber Glass Screw Cap Vial (810207X-50ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

67-56-1 + 67-66-3

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Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior
Hakogi T, et al.
Bioorganic & Medicinal Chemistry Letters, 13(4), 661-664 (2003)
Sphingosine-1-phosphate phosphatase 2 regulates pancreatic islet beta-cell endoplasmic reticulum stress and proliferation
Taguchi Y, et al.
The Journal of Biological Chemistry, 291(23), 12029-12038 (2016)
Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes
Ito K, et al.
Biochemical and biophysical research communications, 357(1), 212-217 (2007)
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