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860463P

Avanti

N-C16-desoxymethylsphinganine

Avanti Research™ - A Croda Brand

Synonym(s):

N-palmitoyl-1-desoxymethylsphinganine (m17:0/16:0)

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About This Item

Empirical Formula (Hill Notation):
C33H67NO2
CAS Number:
1246298-42-9
Molecular Weight:
509.89
MDL number:
MFCD22416667
UNSPSC Code:
12352211
NACRES:
NA.25
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Product Name

N-C16-desoxymethylsphinganine, Avanti Research™ - A Croda Brand 860463P, powder

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (860463P-1mg), pkg of 1 × 5 mg (860463P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860463P

lipid type

sphingolipids
bioactive lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](CCCCCCCCCCCCCCC)(O)CNC(CCCCCCCCCCCCCCC)=O

InChI

1S/C33H67NO2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-32(35)31-34-33(36)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h32,35H,3-31H2,1-2H3,(H,34,36)/t32-/m1/s1

InChI key

SCCABQBVDWFVHP-JGCGQSQUSA-N

General description

N-C16-desoxymethylsphinganine is the N-acylated form of 1-desoxymethylsphinganine, a potent inhibitor of sphingolipid metabolism. Ceramide synthases (CerS) catalyzes the acylation of sphingoid bases using fatty acyl-CoA and its inhibition results in decrease of N-acylsphinganines (dihydroceramides) levels and accumulation of sphinganine. Dihydroceramides (DHCer) are intermediates of ceramide biosynthesis.

Biochem/physiol Actions

Dihydroceramides are also used for dihydrosphingolipids synthesis. Treatment of MCF7 cancer cells with fenretinide alters sphingolipid metabolism.

Packaging

5 mL Amber Glass Screw Cap Vial (860463P-1mg)
5 mL Amber Glass Screw Cap Vial (860463P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk

WGK 3

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