Product Name
18:1 PEG5000 PE, Avanti Research™ - A Croda Brand 880230P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 2 × 100 mg (880230P-200mg), pkg of 1 × 25 mg (880230P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 880230P
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(OCCNC([(OCH2CH2)113OCH3])=O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]
Application
18:1 PEG5000 PE or 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000 may be used in lipid bilayer preparation, and DOX free base loaded mixed dendrimer micelles (MDM DOX) preparation for tumor targeted delivery of siRNA and drugs.
Biochem/physiol Actions
18:1 PEG5000 PE, also referred as 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] (PEG5k-DOPE) in combination with lipid modified dendrimer copolymer supports co-delivery of siRNA and drugs to tumors.
Packaging
5 mL Clear Glass Sealed Ampule (880230P-200mg)
5 mL Clear Glass Sealed Ampule (880230P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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TCR--pMHC bond conformation controls TCR ligand discrimination
Sasmal DK, et al.
Cellular & Molecular Immunology (2019)
Xiaozheng Xu et al.
The Journal of cell biology, 219(6) (2020-05-22)
Blockade antibodies of the immunoinhibitory receptor PD-1 can stimulate the anti-tumor activity of T cells, but clinical benefit is limited to a fraction of patients. Evidence suggests that BTLA, a receptor structurally related to PD-1, may contribute to resistance to