04-901
Anti-NR2A Antibody, clone A12W, rabbit monoclonal
culture supernatant, clone A12W, Upstate®
Synonym(s):
Anti-EPND, Anti-FESD, Anti-GluN2A, Anti-LKS, Anti-NMDAR2A, Anti-NR2A
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
A12W, monoclonal
Application:
WB
Citations:
25
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
A12W, monoclonal
species reactivity
mouse, rat
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... GRIN2A(2903)
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General description
Mr 170kDa
Immunogen
6His-tagged fusion protein corresponding to amino acids 1265-1464 of mouse NMDA receptor 2A (NR2A)
Application
Anti-NR2A Antibody, clone A12W is an antibody against NR2A for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
Biochem/physiol Actions
NR2A
Physical form
Cultured supernantant in 0.05% sodium azide
Preparation Note
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
routinely evaluated by immunoblot on rat brain microsomal preparations (Catalog#12-144)
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function.
Kiraly, DD; Lemtiri-Chlieh, F; Levine, ES; Mains, RE; Eipper, BA
The Journal of Neuroscience null
Marie Lise Frandemiche et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(17), 6084-6097 (2014-04-25)
Tau is a microtubule-associated protein well known for its stabilization of microtubules in axons. Recently, it has emerged that tau participates in synaptic function as part of the molecular pathway leading to amyloid-beta (Aβ)-driven synaptotoxicity in the context of Alzheimer's
Chihiro Nozaki et al.
Nature neuroscience, 14(8), 1017-1022 (2011-07-05)
Zinc is abundant in the central nervous system and regulates pain, but the underlying mechanisms are unknown. In vitro studies have shown that extracellular zinc modulates a plethora of signaling membrane proteins, including NMDA receptors containing the NR2A subunit, which
Melissa A Snyder et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(2), 328-340 (2012-09-13)
The N-methyl-D-aspartate (NMDA) receptor has long been associated with learning and memory processes as well as diseased states, particularly in schizophrenia (SZ). Additionally, SZ is increasingly recognized as a neurodevelopmental disorder with cognitive impairments often preceding the onset of psychosis.
Visualization of structural changes accompanying activation of N-methyl-D-aspartate (NMDA) receptors using fast-scan atomic force microscopy imaging.
Suzuki, Y; Goetze, TA; Stroebel, D; Balasuriya, D; Yoshimura, SH; Henderson, RM; Paoletti et al.
The Journal of Biological Chemistry null
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 04-901 | 04053252586293 |
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