19-143
PD 98059
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405
form
solid
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
shipped in
wet ice
Quality Level
Application
Potent, selective and cell-permeable inhibitor of MAPK kinase, MAPK/ERK, or MEKK.
Biochem/physiol Actions
Inhibitor Type: Kinase
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Physical form
C16H13NO3
Preparation Note
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
Certificates of Analysis (COA)
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D R Alessi et al.
The Journal of biological chemistry, 270(46), 27489-27494 (1995-11-17)
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1) and a mutant MAPKK1(S217E,S221E), which has low levels of constitutive activity (Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., and
L Pang et al.
The Journal of biological chemistry, 270(23), 13585-13588 (1995-06-09)
The mitogen-activated protein kinase (MAP kinase) pathway is thought to play an important role in the actions of neurotrophins. A small molecule inhibitor of the upstream kinase activator of MAP kinase, MAP kinase kinase (MEK) was examined for its effect
Qize Wei et al.
Molecular biology of the cell, 13(2), 683-697 (2002-02-21)
We ectopically expressed the transcription factor Pitx2a, one of the Pitx2 isoforms, in HeLa cells by using a tetracycline-inducible expression system and examined whether Pitx2a was capable of modulating Rho GTPase signaling and altering the cell's cytoskeleton. Ectopic expression of
Yan-Wei Wu et al.
Materials today. Bio, 17, 100480-100480 (2022-11-11)
Most existing vaccines use activators that polarize the immune response to T-helper (Th) 2 response for antibody production. Our positively charged chitosan (Cs)-based nanocomplex (CNC) drives the Th1 response through unknown mechanisms. As receptors for the positively charged CNC are
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 19-143 | 04053252590498 |
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