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343922

5-Fluorouracil

≥98% (HPLC), solid, thymidylate synthase inhibitor, Calbiochem®

Synonym(s):

5-Fluorouracil, 5-FU

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About This Item

Empirical Formula (Hill Notation):
C4H3FN2O2
CAS Number:
51-21-8
Molecular Weight:
130.08
UNSPSC Code:
12171500
NACRES:
NA.77
MDL number:
MFCD00006018
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
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Product Name

5-Fluorouracil, Potent antitumor agent.

description

Merck USA index - 14, 4181

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

hot water: 1 mg/mL, methanol: 1 mg/mL, DMF: 5 mg/mL, DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Fc1[c]([nH][c]([nH]c1)=O)=O

InChI

1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key

GHASVSINZRGABV-UHFFFAOYSA-N

General description

Potent antitumor agent that inhibits aminoisobutyrate-pyruvate aminotransferase. Induces apoptosis of human colon cancer cell lines.
Potent antitumor agent. Inhibits aminoisobutyrate-pyruvate aminotransferase. Induces apoptosis in human colon cancer cell lines.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Aminoisobutyrate-pyruvate aminotransferase
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pressacco, J., et al. 1996. Br. J. Cancer72, 939.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H351

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Certificates of Analysis (COA)

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