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Merck

36-008-C

Anti-α-Synuclein (SNCA) Antibody

mouse monoclonal, Syn211

Synonym(s):

Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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Product Name

Anti-alpha-Synuclein (aa 121-125) Antibody, clone Syn211 (Ascites Free), clone Syn211, from mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

Syn211, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_000336

UniProt accession no.

P37840

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SNCA(6622)

Analysis Note

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected alpha-Synuclein in 10 µg of human brain tissue lysate.

Application

Anti-alpha-Synuclein (aa 121-125) Antibody, clone Syn211 (Ascites Free) is an antibody against alpha-Synuclein for use in Immunohistochemistry and Western Blotting.
Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected alpha-Synuclein in human cerebral cortex and human kidney tissue.
Western Blotting Analysis: A representative lot detected alpha-Synuclein in Synucleinopathy brains (Guo, J.L., et al. (2013). Cell. 154:103-117).

General description

Alpha-synuclein is encoded by the SNCA gene (also known as NACP, PARK1) in human. There are two other known synuclein family members, beta- and gamma-synuclein. Interest in synuclein research started with the discovery of alpha-synuclein mutation in several families with autosomal dominant Parkinson′s disease (PD). Alpha-synuclein is abundantly expressed in the brain and is found in a classic amyloid fibril form within the intra-neuronal Lewy body deposits of PD. The physiological function of synucleins is not well understood, but appears to involve membrane interactions, and in particular reversible binding to synaptic vesicle membranes. Contradictory evidences regarding inhibitory action of alpha-synuclein against phospholipase D (PLD) have been reported (PMID 11821392 & 19146388). Clone Syn211, Cat. No. 36-008-C detects epitope in the region from amino acid 121 to 125 and has been used together with clone LB509, Cat. No. MABN824, to characterize the digestion pattern of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al. 2013; PMID 23827677).
~15 kDa observed

Immunogen

Conjugated recombinant protein corresponding to human alpha-Synuclein.
Epitope: alpha-syn 121-125

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Format: Purified

Preparation Note

Stable for 1 year at 2-8°Cfrom date of receipt.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Distinct ?-synuclein strains differentially promote tau inclusions in neurons.
Guo, JL; Covell, DJ; Daniels, JP; Iba, M; Stieber, A; Zhang, B; Riddle, DM; Kwong, LK; Xu et al.
Cell null

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White Paper: Further considerations of antibody validation and usage.

Global Trade Item Number

SKUGTIN
36-008-C04055977161922

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