CBL186
Anti-DNA Antibody, clone AC-30-10
clone AC-30-10, Chemicon®, from mouse
Synonym(s):
Deoxyribonucleic acid
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
AC-30-10, monoclonal
Technique(s):
immunofluorescence: suitable, immunohistochemistry: suitable (paraffin)
Application:
IF, IHC
Citations:
11
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
AC-30-10, monoclonal
species reactivity (predicted by homology)
all
manufacturer/tradename
Chemicon®
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable (paraffin)
isotype
IgM
shipped in
wet ice
target post-translational modification
unmodified
Application
Anti-DNA Antibody, clone AC-30-10 is a Mouse Monoclonal Antibody for the detection of DNA & has been validated in IF, IHC(P).
Research (cell biology, molecular biology, microbiology) since it reacts with any form of native and denatured DNA. Reliable positive control in immunofluoresence assays for detecting DNA antibodies on tissues of cultured cells, notably in the diagnosis of autoantibodies and autoimmune diseases.
Sensitive detection of mycoplasma contamination in cell cultures.
For frozen and paraffin tissue sections.
Optimal working dilutions must be determined by the end user.
Sensitive detection of mycoplasma contamination in cell cultures.
For frozen and paraffin tissue sections.
Optimal working dilutions must be determined by the end user.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair
Cell Cycle, DNA Replication & Repair
Biochem/physiol Actions
This antibody reacts with native denatured DNA extracted from various organisms: mouse DNA, calf thymus DNA, M13 DNA, SV-40 DNA and several plasmids. It also reacts with synthetic DNA of different base compositions: poly dAT-poly dAT, poly dAT. DNA-containing structures such as chromatin in diverse tissues from several species as well as in diverse cell lines such as XLKE-A6 (Xenopus), RVF-SMC (rat kangaroo) and HeLa (human) are also recognized.
Physical form
Format: Purified
The immunoglobulin was purified by gel filtration and presented in PBS, pH 7.4, containing 0.09% sodium azide and 0.5% BSA.
Preparation Note
Maintain at 2-8°C for up to 12 months from date of receipt.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Genome-wide analysis reveals coating of the mitochondrial genome by TFAM.
Wang, YE; Marinov, GK; Wold, BJ; Chan, DC
Testing null
U Scheer et al.
European journal of cell biology, 43(3), 358-371 (1987-06-01)
A monoclonal antibody (AK 30-10) is described which specifically reacts with DNA both in double and single-stranded forms but not with other molecules and structures, including deoxyribonucleotides and RNAs. When used in immunocytochemical experiments on tissue sections and permeabilized cultured
Sebastian Aguirre et al.
Nature microbiology, 2, 17037-17037 (2017-03-28)
During the last few decades, the global incidence of dengue virus (DENV) has increased dramatically, and it is now endemic in more than 100 countries. To establish a productive infection in humans, DENV uses different strategies to inhibit or avoid
Pedro Silva-Pinheiro et al.
Nucleic acids research, 49(9), 5230-5248 (2021-05-07)
Mutations in POLG, encoding POLγA, the catalytic subunit of the mitochondrial DNA polymerase, cause a spectrum of disorders characterized by mtDNA instability. However, the molecular pathogenesis of POLG-related diseases is poorly understood and efficient treatments are missing. Here, we generate
Jingyi Guo et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(10), 2004680-2004680 (2021-05-25)
Mitochondrial DNA depletion syndrome (MDS) is a group of severe inherited disorders caused by mutations in genes, such as deoxyribonucleoside kinase (DGUOK). A great majority of DGUOK mutant MDS patients develop iron overload progressing to severe liver failure. However, the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| CBL186 | 04053252409417 |
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