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Merck

MAB4343

Anti-SOX2 Antibody

CHEMICON®, mouse monoclonal, 6F1.2

Synonym(s):

Anti-ANOP3, Anti-MCOPS3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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Product Name

Anti-SOX-2 Antibody, clone 6F1.2, Chemicon®, from mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6F1.2, monoclonal

species reactivity

mouse, human

packaging

antibody small pack of 25 μg

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

input

sample type: mouse embryonic stem cell(s)
sample type neural stem cell(s)
sample type: human embryonic stem cell(s)
sample type induced pluripotent stem cell(s)

isotype

IgG2b

NCBI accession no.

NM_003106.2

UniProt accession no.

P48431

shipped in

ambient

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SOX2(6657)
mouse ... Sox2(20674)

Related Categories

Analysis Note

Tested

Application

Anti-SOX-2 Antibody detects level of SOX-2 & has been published & validated for use in IC, IH & WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS.
~34 kDa

Immunogen

Recombinant GST Fusion protein.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified
Purified Immunoglobulin by protein A affinity chromatography and presented as a liquid in 0.02 M phosphate buffer, pH 7.6, with 0.25 M NaCl. Contains 0.1% sodium azide.

Preparation Note

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Knockdown of cancer testis antigens modulates neural stem cell marker expression in glioblastoma tumor stem cells.
Low, J; Dowless, M; Shiyanova, T; Rowlinson, S; Ricci-Vitiani, L; de Maria, R; Pallini et al.
Journal of Biomolecular Screening null
Knockdown of ubiquitin ligases in glioblastoma cancer stem cells leads to cell death and differentiation.
Low, J; Blosser, W; Dowless, M; Ricci-Vitiani, L; Pallini, R; de Maria, R; Stancato, L
Journal of Biomolecular Screening null
Jingli Cai et al.
Developmental biology, 251(2), 221-240 (2002-11-19)
Multipotent neural stem cells (NSCs) present in the developing neural tube (E10.5, neuroepithelial cells; NEP) were examined for the expression of candidate stem cell markers, and the expression of these markers was compared with later appearing precursor cells (E14.5) that
Masoumeh Fakhr Taha et al.
BioMed research international, 2014, 941486-941486 (2014-08-26)
The expression pattern of pluripotency markers in adipose tissue-derived stem cells (ADSCs) is a subject of controversy. Moreover, there is no data about the signaling molecules that regulate these markers in ADSCs. In the present study, we studied the roles
High-content imaging-based screening of microenvironment-induced changes to stem cells.
Vega, SL; Liu, E; Patel, PJ; Kulesa, AB; Carlson, AL; Ma, Y; Becker, ML; Moghe, PV
Journal of Biomolecular Screening null
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Related Content

Human Stem Cell Systems

As the focus of stem cell research undergoes a transition from animal to human models, researchers are in critical need of validated products to support the isolation, maintenance, differentiation, and characterization of human stem cells. While many reagents designed for rodent systems can be applied to human stem cell studies, they are not truly optimized for robust human stem cell culture or analysis. This is why human stem cell researchers have always trusted EMD Millipore, the first provider of commercially available human embryonic stem cells and human neural stem cell lines, to accelerate their research. All of our human stem cell systems are extensively tested in defined media culture, and differentiated progeny are comprehensively characterized with highly validated antibodies and detection reagents.

Global Trade Item Number

SKUGTIN
MAB434304053252316838
MAB4343-25UG04054839342721

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