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Merck

32473

Metoclopramide

VETRANAL®, analytical standard

Synonym(s):

4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide, Methoxychloroprocainamide

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About This Item

Empirical Formula (Hill Notation):
C14H22ClN3O2
CAS Number:
364-62-5
Molecular Weight:
299.80
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754232
EC Number:
206-662-9
Beilstein/REAXYS Number:
1884366
MDL number:
MFCD00211338

Key Documents

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Product Name

Metoclopramide, VETRANAL®, analytical standard

InChI

1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)

SMILES string

CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC

InChI key

TTWJBBZEZQICBI-UHFFFAOYSA-N

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... DRD2(1813), HTR3A(3359), HTR4(3360)

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Application

Metoclopramide may be used as a reference standard for the determination of the analyte in serum samples using reversed-phase high-performance liquid chromatography (RP-HPLC) with electrochemical detection.
Metoclopramide may be used as an analytical reference standard for the determination of the analyte in:
  • Human plasma by liquid–liquid extraction (LLE) with dichloromethane followed by hydrophilic interaction chromatography-electrospray iionization-tandem mass spectrometry (HILIC-ESI-MS/MS) operating in selected reaction monitoring (SRM) mode of detection.

It may also be used as an internal standard for the determination of loratadine and desloratadine in:
  • Human plasma by high performance liquid chromatography (HPLC) coupled to MS/MS with multiple reaction monitoring (MRM) detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Metoclopramide is a drug, which can be effective in the treatment of severe nausea and vomiting caused by the anticancer drug cis-platinum.
Metoclopramide is typically employed as an antiemetic drug or a gastrointestinal prokinetic drug in adults and children.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ1051
BCCC9314
BCBZ4989
BCBS3944V

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Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection.
Vlase L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 44(3), 652-657 (2007)
G S De Oliveira et al.
British journal of anaesthesia, 109(5), 688-697 (2012-09-28)
Previous evidence suggested that 10 mg systemic metoclopramide is not effective to prevent postoperative nausea and/or vomiting (PONV) in patients receiving general anaesthesia. However, the evidence included data with questioned validity by the author Yoshitaka Fujii. The objective of the
Metoclopramide: pharmacology and clinical application.
Albibi R and McCALLUM RW
Annals of Internal Medicine, 98(1), 86-95 (1983)
Determination of metoclopramide in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry.
Lee HW, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 877(18-19), 1716-1720 (2009)
Double-blind crossover study of the antiemetic efficacy of high-dose dexamethasone versus high-dose metoclopramide.
Aapro SM, et al.
Journal of Clinical Oncology, 2(5), 466-471 (1984)
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