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Merck

P9672

Probucol

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C31H48O2S2
CAS Number:
23288-49-5
Molecular Weight:
516.84
NACRES:
NA.24
PubChem Substance ID:
329820354
UNSPSC Code:
41116107
EC Number:
245-560-9
MDL number:
MFCD00079281

Key Documents

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Product Name

Probucol, analytical standard

InChI key

FYPMFJGVHOHGLL-UHFFFAOYSA-N

InChI

1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3

SMILES string

CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

200

Gene Information

human ... ABCA1(19), IL1B(3553), IL6(3569), TNF(7124)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Enhances selective uptake of HDL-associated cholesteryl esters.

General description

Probucol is a diphenolic compound possessing antioxidant and anti-inflammatory properties. It is commercially used as a lipid lowering drug, which helps in reducing the total plasma cholesterol, low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL).

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCM2132
SLBS3412V
SLBR2496V
MKBQ8447V
SLBD2845V

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Zhiwen Zhang et al.
International journal of pharmaceutics, 444(1-2), 162-168 (2013-01-24)
The therapeutic efficacy of lipophilic drugs is commonly restricted by the low systemic exposure after oral administration. In this work, a new delivery system combining the advantages of porous starch and self-assembled nanocarrier was designed to improve the oral absorption
Atherosclerosis: Treatment and Prevention (2012)
Miwako Inagaki et al.
Journal of atherosclerosis and thrombosis, 19(7), 643-656 (2012-07-13)
High density lipoprotein (HDL) has multi-antiatherogenic effects such as antioxidation and anti-inflammation, in addition to being a key mediator of reverse cholesterol transport. Probucol, known as a lipid lowering drug, is also a potent antioxidant, but it decreases serum HDL
Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics (2013)
Jonathan Watt et al.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 81(4), 698-708 (2012-05-15)
The aim of this study was to assess the efficacy of stent-based delivery of succinobucol alone and in combination with rapamycin in a porcine coronary model. Current drugs and polymers used to coat coronary stents remain suboptimal in terms of
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