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Merck

PHR1115

Stearyl Alcohol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

1-Octadecanol, Octadecyl alcohol, Stearyl alcohol

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About This Item

Linear Formula:
CH3(CH2)17OH
CAS Number:
112-92-5
Molecular Weight:
270.49
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823136
EC Number:
204-017-6
Beilstein/REAXYS Number:
1362907
MDL number:
MFCD00002823

Key Documents

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InChI

1S/C18H38O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19/h19H,2-18H2,1H3

InChI key

GLDOVTGHNKAZLK-UHFFFAOYSA-N

SMILES string

CCCCCCCCCCCCCCCCCCO

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. S1350000, traceable to USP 1622000

vapor density

9.3 (vs air)

vapor pressure

<0.01 mmHg ( 38 °C)

API family

stearyl alcohol

CofA

current certificate can be downloaded

autoignition temp.

842 °F

expl. lim.

~8 %

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

56-59 °C (lit.)

density

0.812 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

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General description

Stearyl Alcohol is added as a stiffening agent in cosmetics and pharmaceutical formulations. It is also utilized to enhance the water-holding capacity of ointments. Its other applications include the use in controlled-release tablets, suppositories, and microspheres.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Stearyl Alcohol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by gas chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7161 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

383.0 °F - closed cup

flash_point_c

195 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Stearyl Alcohol
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 40(2), 6072-6072 (2015)
Handbook of Pharmaceutical Excipients 6th edition Pharmaceutical Press (2009)
M D Koone et al.
Archives of dermatology, 126(11), 1485-1490 (1990-11-01)
A number of inherited disorders of cornification have been related to abnormal lipid metabolism. In the recessively inherited Sjögren-Larsson syndrome, defined by the triad of ichthyosis, mental retardation, and spasticity, fatty alcohol:NAD+ oxidoreductase deficiency has recently been reported. These patients
A Antonelli et al.
Nanotechnology, 21(42), 425101-425101 (2010-09-23)
Single-walled carbon nanotubes (SWNTs) due to their unique structural and physicochemical properties, have been proposed as delivery systems for a variety of diagnostic and therapeutic agents. However, SWNTs have proven difficult to solubilize in aqueous solution, limiting their use in
Laura Carreto et al.
Biophysical journal, 82(1 Pt 1), 530-540 (2001-12-26)
As a model for the epicuticular wax layer of plant cuticular membranes, we have studied the phase behavior of 1-tetradecanol and 1-octadecanol and their binary mixtures between 5 and 70 degrees C, using differential scanning calorimetry and Fourier transform infrared
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