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Merck

PHR1326

Calcium carbonate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Calcium carbonate

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About This Item

Linear Formula:
CaCO3
CAS Number:
471-34-1
Molecular Weight:
100.09
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823311
EC Number:
207-439-9
Beilstein/REAXYS Number:
8008338
MDL number:
MFCD00010906

Key Documents

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Product Name

Calcium carbonate, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

VTYYLEPIZMXCLO-UHFFFAOYSA-L

InChI

1S/CH2O3.Ca/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2

SMILES string

[Ca++].[O-]C([O-])=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1086403

API family

calcium carbonate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

density

2.93 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Calcium carbonate is a material that is widely found in nature, and is commonly referred to as calcite. Calcium carbonate is used in such processes as the manufacture of paper, paints, glass, and ceramics, the compounding of polymers, environmental applications such as wastewater treatment, and as an extender in paints and coatings.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3446 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

13 - Non Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ling Li et al.
Nature materials, 13(5), 501-507 (2014-04-01)
Hierarchical composite materials design in biological exoskeletons achieves penetration resistance through a variety of energy-dissipating mechanisms while simultaneously balancing the need for damage localization to avoid compromising the mechanical integrity of the entire structure and to maintain multi-hit capability. Here
Polysaccharides and proteoglycans in calcium carbonate-based biomineralization.
José L Arias et al.
Chemical reviews, 108(11), 4475-4482 (2008-07-26)
Archan Dey et al.
Chemical Society reviews, 39(2), 397-409 (2010-01-30)
The often astonishing material properties of crystalline biominerals are generally related to the hierarchical assembly of specifically interacting organic and inorganic components. To synthesize new materials with similar advanced properties applying nature's biomimeralization strategies we need to unravel the mechanisms
Calcium carbonate urolithiasis in an adult male cynomolgus monkey.
C M O'Rourke et al.
Laboratory animal science, 45(2), 222-224 (1995-04-01)
Dongni Ren et al.
Micron (Oxford, England : 1993), 42(3), 228-245 (2010-10-19)
The review focuses on the effects of several important additives and templates controlling the calcium carbonate crystals formation and the complexity of the crystal morphologies in vitro. Additives include soluble matrices extracted from shells and pearls, amino-acids, magnesium ions and
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