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Merck

34857

1,4-Dioxane

suitable for HPLC, ≥99.5%

Synonym(s):

Diethylene oxide, Dioxane

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About This Item

Empirical Formula (Hill Notation):
C4H8O2
CAS Number:
123-91-1
Molecular Weight:
88.11
UNSPSC Code:
41116105
NACRES:
NA.21
PubChem Substance ID:
329755066
EC Number:
204-661-8
Beilstein/REAXYS Number:
102551
MDL number:
MFCD00006571
Grade:
HPLC grade
Assay:
≥99.5%
Technique(s):
HPLC: suitable
Application(s):
food and beverages
Bp:
100-102 °C (lit.)
Vapor pressure:
27 mmHg ( 20 °C)
40 mmHg ( 25 °C)

Key Documents

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Product Name

1,4-Dioxane, suitable for HPLC, ≥99.5%

InChI key

RYHBNJHYFVUHQT-UHFFFAOYSA-N

InChI

1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2

SMILES string

C1COCCO1

grade

HPLC grade

vapor density

3 (vs air)

vapor pressure

27 mmHg ( 20 °C)
40 mmHg ( 25 °C)

assay

≥99.5%

form

liquid

autoignition temp.

356 °F

expl. lim.

22 %

technique(s)

HPLC: suitable

impurities

≤0.001% non-volatile matter
≤0.002% free acid (as CH3COOH)
≤0.01% peroxides (as H2O2)
≤0.05% water (Karl Fischer)

transmittance

220 nm, ≥20%
270 nm, ≥80%
300 nm, ≥98%

refractive index

n20/D 1.422 (lit.)

pH

6.0-8 (20 °C, 500 g/L)

bp

100-102 °C (lit.)

mp

10-12 °C (lit.)

density

1.034 g/mL at 25 °C (lit.)

UV absorption

λ: 220 nm Amax: ≤0.70
λ: 235 nm Amax: ≤0.50
λ: 250 nm Amax: ≤0.20
λ: 270 nm Amax: ≤0.10
λ: 295-400 nm Amax: ≤0.01

application(s)

food and beverages

Quality Level

100

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Related Categories

Application

1,4-Dioxane may be employed as a solvent in the synthesis of N-(4-(prop-2-ynyloxy)phenyl)acetamide and 3-(4-(prop-2-ynyloxy)phenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine.
High-purity, multipurpose solvent, tested for suitability in:
  • HPLC
  • Spectrophotometry
  • Residual testing
  • LC-MS applications.

Reported as a solvent in:
  • HPLC-MS study of fat-soluble vitamins (FSVs)
  • GC-MS analysis of phthalates in workplace air

Suitable for HPLC, spectrophotometry, environmental testing

General description

1,4-Dioxane is widely used as a solvent for various organic compounds in industry. It is a non-biodegradable contaminant found in industrial effluents. Its oxidative degradation by using oxygen and ozone has been useful in converting it into biodegradable products, which can be easily removed by conventional methods.

Other Notes

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

signalword

Danger

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Respiratory system

supp_hazards

EUH019,EUH066

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
STBL1101
STBK4510
STBK3338
STBK2985
MKCQ4143

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Oxidation and biodegradability enhancement of 1,4-dioxane using hydrogen peroxide and ozone.
C D Adams et al.
Environmental science & technology, 28(11), 1812-1818 (1994-10-01)
Self-curable benzoxazine functional polybutadienes synthesized by click chemistry.
Kukut M, et al.
Designed Monomers and Polymers, 12(2), 167-176 (2009)
Xiaohua Liu et al.
Biomaterials, 31(2), 259-269 (2009-09-29)
It remains a challenge to synthesize functional materials that can develop advanced scaffolding architectures for tissue engineering. In this study, a series of biodegradable amphiphilic poly(hydroxyalkyl (meth)acrylate)-graft-poly(l-lactic acid) (PHAA-g-PLLA) copolymers have been synthesized and fabricated into nano-fibrous scaffolds. These copolymers
Joshua J Pacheco et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(23), 8363-8367 (2014-06-10)
Terephthalic acid (PTA), a monomer in the synthesis of polyethylene terephthalate (PET), is obtained by the oxidation of petroleum-derived p-xylene. There is significant interest in the synthesis of renewable, biomass-derived PTA. Here, routes to PTA starting from oxidized products of
Daniel Gerrity et al.
Water research, 46(19), 6257-6272 (2012-10-16)
The performance of ozonation in wastewater depends on water quality and the ability to form hydroxyl radicals (·OH) to meet disinfection or contaminant transformation objectives. Since there are no on-line methods to assess ozone and ·OH exposure in wastewater, many
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