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Merck

30070

Cysteamine

≥98.0% (RT)

Synonym(s):

β-Mercaptoethylamine, 2-Aminoethanethiol, 2-Mercaptoethylamine, Decarboxycysteine, MEA, Thioethanolamine

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About This Item

Linear Formula:
NH2CH2CH2SH
CAS Number:
60-23-1
Molecular Weight:
77.15
UNSPSC Code:
12352116
NACRES:
NA.25
PubChem Substance ID:
57648397
EC Number:
200-463-0
Beilstein/REAXYS Number:
635649
MDL number:
MFCD00008196

Key Documents

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Product Name

Cysteamine, ≥98.0% (RT)

InChI key

UFULAYFCSOUIOV-UHFFFAOYSA-N

InChI

1S/C2H7NS/c3-1-2-4/h4H,1-3H2

SMILES string

NCCS

assay

≥98.0% (RT)

storage temp.

2-8°C

Quality Level

200

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Application

Cysteamine is suitable for use:
  • in the preparation of cysteamine modified gold nanoparticles (AuNP)
  • in the fabrication of SU-8 microrods, where in, the amine group of cysteamine reacts with the unreacted epoxide rings present on the surface of the particles, thereby opening it and forming a covalent bond
  • to enhance in vitro development of porcine oocytes matured and fertilized in vitro
  • in a study to demonstrate the depletion effect of cysteamine on cystinotic leucocyte granular fractions of cystine by disulphide interchange
  • as a radioprotector
  • to administer subcutaneously in rats to study its blocking effect on somatostatin secretion without modifying the pancreatic insulin or glucagon content
  • as a scavenger in electrophoretic gels (acetic acid/urea gels)

Biochem/physiol Actions

Cysteamine (β-mercaptoethylamine) depletes cystine from patient′s cells and there by regulates renal glomerular function and increases growth in them. Therefore, cysteamine is considered to be a potential therapeutic for nephropathic cystinosis.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG8927
BCCB5117
BCCG2678
BCBX0781
BCBT3349

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J Carmichael et al.
Cancer research, 47(4), 943-946 (1987-02-15)
Radiation survival curves were generated for V79 Chinese hamster and two human lung cancer cell lines (NCI-H460 and NCI-H249) with doubling times of 10, 20, and 85 h, respectively, using a standard clonogenic assay, a dye exclusion assay, and a
Automatic microcircuit formation based on gold-coated SU-8 microrods via dielectrophoresis.
Yu-Kun R, et al.
Chinese Physics B, 22 (2013)
C G Grupen et al.
Biology of reproduction, 53(1), 173-178 (1995-07-01)
Most porcine oocytes matured and fertilized in vitro fail to develop normally due to abnormal fertilization. The aim of this study was to determine the effect of cysteamine on pronuclear formation and developmental competence in pig embryos produced in vitro.
R L Sorenson et al.
Diabetes, 32(4), 377-379 (1983-04-01)
Cysteamine (300 mg/kg) administered subcutaneously depletes pancreatic somatostatin to 36% of control levels, but does not alter pancreatic insulin or glucagon content. Although perfusion of pancreata from normal animals with glucose (300 mg/dl) markedly stimulated somatostatin release, pancreata from cysteamine-treated
Cysteamine therapy for children with nephropathic cystinosis
Gahl WA, et al.
The New England Journal of Medicine, 316(16), 971-977 (2018)
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