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Merck

40234

N,N-Dimethyldodecylamine N-oxide

BioXtra, ≥99.0% (NT)

Synonym(s):

DDAO, LDAO, Lauryldimethylamine N-oxide

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About This Item

Linear Formula:
CH3(CH2)11N(O)(CH3)2
CAS Number:
1643-20-5
Molecular Weight:
229.40
UNSPSC Code:
12161902
NACRES:
NA.26
PubChem Substance ID:
57649946
EC Number:
216-700-6
Beilstein/REAXYS Number:
1769927
MDL number:
MFCD00002049

Key Documents

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Product Name

N,N-Dimethyldodecylamine N-oxide, BioXtra, ≥99.0% (NT)

InChI key

SYELZBGXAIXKHU-UHFFFAOYSA-N

InChI

1S/C14H31NO/c1-4-5-6-7-8-9-10-11-12-13-14-15(2,3)16/h4-14H2,1-3H3

SMILES string

CCCCCCCCCCCC[N+](C)(C)[O-]

description

non-ionic
sulfate (ICP): ≤ 50 mg/kg

product line

BioXtra

assay

≥99.0% (NT)

form

powder

mol wt

229.40 g/mol

technique(s)

protein quantification: suitable

impurities

≤0.03% peroxides (as H2O2)

CMC

1-2 mM

mp

132-133 °C (lit.)

anion traces

chloride (Cl-): ≤100 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤100 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

storage temp.

2-8°C

Quality Level

200

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Application

N,N-Dimethyldodecylamine N-oxide has been used in the cell lysis and resuspension of cell pellets for western blot analysis.

General description

N,N-Dimethyldodecylamine N-oxide is a non-denaturing zwitterionic surfactant with a critical micelle concentration (CMC) of approximately 1 mM. It is used to solubilize proteins and to study the conformation and molecular interactions of macromolecules.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000143951
BCCG6905
BCCF8604
0000118930
0000097925

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Eugenio Daviso et al.
Journal of the American Chemical Society, 133(42), 16754-16757 (2011-10-04)
Several techniques rely on electron-nuclear interactions to boost the polarization of nuclear spins in the solid phase. Averaging out of anisotropic interactions as a result of molecular tumbling strongly reduces the applicability of such hyperpolarization approaches in liquids. Here we
Gerardo Palazzo et al.
Biochimica et biophysica acta, 1804(1), 137-146 (2009-09-30)
We report on the response of reaction center (RC) from Rhodobacter sphaeroides (an archetype of membrane proteins) to the exposure at high temperature. The RCs have been solubilized in aqueous solution of the detergent N,N-dimethyldodecylamine-N-oxide (LDAO). Changes in the protein
Benesh Joseph et al.
The Journal of biological chemistry, 286(47), 41008-41017 (2011-09-29)
ATP-binding cassette (ABC) transporters are ubiquitous integral membrane proteins that translocate substrates across cell membranes. The alternating access of their transmembrane domains to opposite sides of the membrane powered by the closure and reopening of the nucleotide binding domains is
"Self-immolative" spacer for uncaging with fluorescence reporting.
Raphaël Labruère et al.
Angewandte Chemie (International ed. in English), 51(37), 9344-9347 (2012-08-30)
Stefanie Keis et al.
Journal of bacteriology, 188(11), 3796-3804 (2006-05-19)
The F(1)F(o)-ATP synthases of alkaliphilic bacteria exhibit latent ATPase activity, and for the thermoalkaliphile Bacillus sp. strain TA2.A1, this activity is intrinsic to the F(1) moiety. To study the mechanism of ATPase inhibition, we developed a heterologous expression system in
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