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Merck

88315

Thesit®

Synonym(s):

Polyethylene glycol dodecyl ether, Polyethylene glycol 400 dodecyl ether, Hydroxypolyethoxydodecane, Lauromacrogol, Macrogol lauryl ether, Polidocanol

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About This Item

Linear Formula:
HO(CH2CH2O)n(CH2)11CH3
CAS Number:
9002-92-0
NACRES:
NA.21
PubChem Substance ID:
57653299
UNSPSC Code:
12352201
MDL number:
MFCD00080891

Key Documents

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InChI key

IEQAICDLOKRSRL-UHFFFAOYSA-N

SMILES string

CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO

InChI

1S/C58H118O24/c1-2-3-4-5-6-7-8-9-10-11-13-60-15-17-62-19-21-64-23-25-66-27-29-68-31-33-70-35-37-72-39-41-74-43-45-76-47-49-78-51-53-80-55-57-82-58-56-81-54-52-79-50-48-77-46-44-75-42-40-73-38-36-71-34-32-69-30-28-67-26-24-65-22-20-63-18-16-61-14-12-59/h59H,2-58H2,1H3

description

non-ionic

form

solid

mol wt

average mol wt 583

impurities

≤1 ppm peroxides (as H2O2)

CMC

0.1 mM (20-25°C)

Quality Level

200

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Related Categories

Application

Suggested substitute for Lubrol in the preparation of G protein from bovine brain.
Thesit has been used in the reaction buffer to reduce the background sedimentation.

Biochem/physiol Actions

Thesit/Polidocanol possesses in vitro and in vivo anti-angiogenic effects. This sclerosant is mainly used for sclerotherapy.

Legal Information

Thesit is a registered trademark of Desitin Arzneimittel GmbH

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBZ7152
BCCG8019
BCCG7621
BCCF5883
BCCF6227

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K Parsi et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 41(2), 267-277 (2010-12-25)
To investigate the in vitro effects of detergent sclerosants sodium tetradecyl sulphate (STS) and polidocanol (POL) on clot formation and lysis. clot kinetics were assessed in whole blood by thromboelastography (TEG®) and rotational thromboelastometry (ROTEM®). Fibrinogen was measured by the
Polidocanol (Lauromacrogol 400) has anti-angiogenic effects in vitro and in vivo
Doganci S, et al.
European Review for Medical and Pharmacological Sciences, 20(7), 1384-1389 (2016)
Measuring protein binding to F-actin by co-sedimentation
Heier JA, et al.
Journal of Visualized Experiments, e55613-e55613 (2017)
Synthesis and use of biotinylated beta gamma complexes prepared from bovine brain G proteins.
J Dingus et al.
Methods in enzymology, 237, 457-471 (1994-01-01)
Darío Morais et al.
Rhinology, 50(1), 80-86 (2012-04-04)
Hereditary Haemorrhagic Telangiectasia or Rendu-Osler-Weber syndrome is a rare autosomal dominant vascular disease characterized by mucocutaneous and gastrointestinal telangiectases and localized arteriovenous malformations in lung, brain and liver. Epistaxis, due to rupture of telangiectases of the nasal mucosa, is the
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