A9232
AMI-1 sodium salt hydrate
≥98% (HPLC)
Synonym(s):
7,7′-Carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid) sodium salt hydrate
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About This Item
Empirical Formula (Hill Notation):
C21H16N2O9S2 · xNa+ · yH2O
Molecular Weight:
504.49 (anhydrous free acid basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Product Name
AMI-1 sodium salt hydrate, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
protect from light
color
purple
solubility
H2O: >10 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
AMI-1 inhibits arginine, but not lysine, methyltransferase activity in vitro, while not interacting with S-adenosyl methionine (AdoMet), unlike most methyltransferase inhibitors which compete for the AdoMet binding site.
Protein arginine N-methyltransferases (PRMTs) are involved in post-translational modification implicated in protein trafficking, signal transduction, and transcriptional regulation. AMI-1 does not inhibit lysine methyltransferase activity and does not interact with S-adenosylmethionine (AdoMet), unlike most methyltransferase inhibitors which compete for the AdoMet binding site. AMI-1 can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements; and is a HIV-1 reverse transcriptase inhibitor. AMI-1 is a potent antagonist of NADPH-oxidase-derived superoxide production, but acts as a direct antioxidant rather than indirectly through methyltransferase inhibition.
Features and Benefits
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Wenya Hou et al.
Developmental cell, 45(2), 262-275 (2018-04-25)
The complex architecture of neuronal networks in the brain requires tight control of the actin cytoskeleton. The actin nucleator Cobl is critical for neuronal morphogenesis. Here we reveal that Cobl is controlled by arginine methylation. Coprecipitations, coimmunoprecipitations, cellular reconstitutions, and in vitro
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