Skip to Content
Merck

F6889

Famotidine

histamine receptor antagonist

Synonym(s):

N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C8H15N7O2S3
CAS Number:
76824-35-6
Molecular Weight:
337.45
UNSPSC Code:
12352200
PubChem Substance ID:
24278442
NACRES:
NA.77
MDL number:
MFCD00079297
Quality level:
100

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Famotidine,

SMILES string

N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1

InChI key

XUFQPHANEAPEMJ-UHFFFAOYSA-N

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

originator

Johnson & Johnson

Quality Level

100

Gene Information

human ... HRH2(3274)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

Famotidine has been used to test its effect on the human ether-a-go-go-related gene (hERG) binding transfected in HEK293 membrane. It has also been used in polycaprolactone based drug delivery studies.

Biochem/physiol Actions

Famotidine is not effective on muscarinic and nicotinic receptors. It competitively inhibits the secretion of gastric acid and elicits mucosal injury protection.
H2 histamine receptor antagonist; anti-ulcer agent

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCF3833
BCCD5384
BCBT5840
BCBS1881V
BCBN3072V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs
Taha AS, et al.
The New England Journal of Medicine, 334(22), 1435-1439 (1996)
Makoto Anraku et al.
International journal of pharmaceutics, 487(1-2), 142-147 (2015-04-18)
An intermolecular complex formed from a 1:1 weight ratio of chitosan (CS, molecular weight 30 kDa) and sulfobutyl ether β-cyclodextrin (SBE-β-CyD, degree of substitution 7) was less soluble than either of the original components. The release of famotidine from tablets
Polycaprolactone thin-film drug delivery systems: empirical and predictive models for device design
Schlesinger E, et al.
Materials Science and Engineering, C, 57, 232-239 (2015)
Kenichi Yamamoto et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 30(12), 1958-1962 (2012-05-18)
Heterotopic ossification or calcification follows any type of musculoskeletal trauma and is known to occur after arthroplasties of hip, knee, shoulder, or elbow; fractures; joint dislocations; or tendon ruptures. Histamine receptor H2 (Hrh2) has been shown to be effective for
H D Langtry et al.
Drugs, 38(4), 551-590 (1989-10-01)
Famotidine is a highly selective histamine H2-receptor antagonist. In healthy volunteers and patients with acid hypersecretory disease it is approximately 20 to 50 times more potent at inhibiting gastric acid secretion than cimetidine and 8 times more potent than ranitidine
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service