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Merck

G019

Muscimol hydrobromide

≥98% (HPLC), GABAA receptor agonist, solid

Synonym(s):

5-Aminomethyl-3-hydroxyisoxazole hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C4H6N2O2 · HBr
CAS Number:
18174-72-6
Molecular Weight:
195.01
UNSPSC Code:
12352200
PubChem Substance ID:
24278168
NACRES:
NA.77
MDL number:
MFCD00055184

Key Documents

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Product Name

Muscimol hydrobromide, ≥98% (HPLC), solid

SMILES string

Br[H].NCc1cc(O)no1

InChI

1S/C4H6N2O2.BrH/c5-2-3-1-4(7)6-8-3;/h1H,2,5H2,(H,6,7);1H

InChI key

OPZOJWHOZRKYQX-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

off-white to tan

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Biochem/physiol Actions

Muscimol hydrobromide is a GABAA receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
074M4744V
044M4747V
042M4617V
087K4601
016K4604

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Benjamin A Rowland et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7198-7202 (2014-05-23)
Detecting and locating environmental events are markedly enhanced by the midbrain's ability to integrate visual and auditory cues. Its capacity for multisensory integration develops in cats 1-4 months after birth but only after acquiring extensive visual-auditory experience. However, briefly deactivating
Max F K Happel et al.
PloS one, 12(1), e0169461-e0169461 (2017-01-04)
Robust perception of auditory objects over a large range of sound intensities is a fundamental feature of the auditory system. However, firing characteristics of single neurons across the entire auditory system, like the frequency tuning, can change significantly with stimulus
Nandor Ludvig et al.
Behavioural brain research, 286, 293-299 (2015-03-17)
This study investigated the possible influence of the Subdural Pharmacotherapy Device (SPD) on spatial memory in 3 adult, male bonnet macaques (Macaca radiata). The device was implanted in and above the subdural/subarachnoid space and cranium overlaying the right parietal/frontal cortex:
Daniel H O'Connor et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(5), 1947-1967 (2010-02-05)
Linking activity in specific cell types with perception, cognition, and action, requires quantitative behavioral experiments in genetic model systems such as the mouse. In head-fixed primates, the combination of precise stimulus control, monitoring of motor output, and physiological recordings over
Mohammed Z Ariffin et al.
Frontiers in neuroanatomy, 11, 79-79 (2017-10-03)
Cholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and cingulate cortex (Cg). In the present study, we
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