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Merck

M4145

Minoxidil

≥99% (TLC), powder, potassium channel activator

Synonym(s):

6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide

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About This Item

Empirical Formula (Hill Notation):
C9H15N5O
CAS Number:
38304-91-5
Molecular Weight:
209.25
NACRES:
NA.77
PubChem Substance ID:
24277853
UNSPSC Code:
12352200
EC Number:
253-874-2
MDL number:
MFCD00063409
Assay:
≥99% (TLC)
Quality level:
100

Key Documents

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Product Name

Minoxidil, ≥99% (TLC)

InChI key

ZIMGGGWCDYVHOY-UHFFFAOYSA-N

InChI

1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2

SMILES string

NC1=CC(=NC(=N)N1O)N2CCCCC2

assay

≥99% (TLC)

mp

272-274 °C (dec.) (lit.)

originator

Johnson & Johnson

Quality Level

100

Gene Information

human ... KCNJ1(3758)

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Application

Minoxidil has been used as test drug:
  • in dermal papilla spheroid model, to study the effect of hair regeneration
  • administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury
  • administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses

Biochem/physiol Actions

Activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.
Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBT1143
061M1369V
061M1369
017K1558
108F0747

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Establishment of an in vitro organoid model of dermal papilla of human hair follicle
Gupta AC, et al.
Journal of Cellular Physiology, 233(11), 9015-9030 (2018)
J van der Velden et al.
Cellular and molecular life sciences : CMLS, 55(5), 788-798 (1999-06-24)
To investigate whether during cardiac hypertrophy changes occur in contractile protein composition and in mechanical and energetic properties of the myocardium, contractile protein composition, isometric force and adenosine triphosphate (ATP) consumption were studied in control and hypertrophied guinea-pig hearts. Cardiac
C Löffler-Walz et al.
British journal of pharmacology, 123(7), 1395-1402 (1998-05-14)
1. The binding of [3H]-P1075, a potent opener of adenosine-5'-triphosphate-(ATP)-sensitive K+ channels, was studied in a crude heart membrane preparation of the rat, at 37 degrees C. 2. Binding required MgATP. In the presence of an ATP-regenerating system, MgATP supported
H Malhi et al.
The Journal of biological chemistry, 275(34), 26050-26057 (2000-06-22)
To determine whether K(ATP) channels control liver growth, we used primary rat hepatocytes and several human cancer cell lines for assays. K(ATP) channel openers (minoxidil, cromakalim, and pinacidil) increased cellular DNA synthesis, whereas K(ATP) channel blockers (quinidine and glibenclamide) attenuated
A non-human primate model for investigating drug-induced risk of orthostatic hypotension and sympathetic dysfunction: Preclinical correlate to a clinical test
Bhatt S, et al.
Journal of Pharmacological and Toxicological Methods, 73(2), 49-55 (2015)
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