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Merck

N8130

4-Nitrophenyl acetate

esterase substrate, chromogenic, ≥98% (TLC), powder or crystals

Synonym(s):

Acetic acid 4-nitrophenyl ester

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About This Item

Linear Formula:
CH3CO2C6H4NO2
CAS Number:
830-03-5
Molecular Weight:
181.15
NACRES:
NA.32
PubChem Substance ID:
24897853
UNSPSC Code:
12352204
EC Number:
212-593-5
MDL number:
MFCD00007326
Beilstein/REAXYS Number:
515874

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Product Name

4-Nitrophenyl acetate, esterase substrate

InChI key

QAUUDNIGJSLPSX-UHFFFAOYSA-N

InChI

1S/C8H7NO4/c1-6(10)13-8-4-2-7(3-5-8)9(11)12/h2-5H,1H3

SMILES string

CC(=O)Oc1ccc(cc1)[N+]([O-])=O

assay

≥98% (TLC)

form

powder or crystals

mp

75-77 °C (lit.)

storage temp.

−20°C

Quality Level

200

Gene Information

human ... PON1(5444)

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Application

4-Nitrophenyl acetate has been used:
  • to evaluate esterase activity in human embryonic kidney cell line
  • in carbonic anhydrase inhibition assay
  • to study its conversion to p-nitrophenol (p-NP) by the esterase activity of bovine serum albumin
  • as a substrate to determine carboxylesterase (CES) activity in mouse liver cells
  • to study the advantages of bioconjugation of cross-linked enzyme aggregates (CLEAs) and magnetic iron oxide nanoparticles (MIONPs) in magnetic CLEAs matrix

General description

Chromogenic esterase substrate.

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Ox. Sol. 3 - Skin Sens. 1

Storage Class

5.1B - Oxidizing hazardous materials

wgk

WGK 3

flash_point_f

No data available

flash_point_c

No data available

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF7796
BCBW1104
BCBP8051V
BCBK4587V
BCBC5913V

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Ramón Alberto Batista-García et al.
PloS one, 9(8), e105893-e105893 (2014-08-28)
A moderate halophile and thermotolerant fungal strain was isolated from a sugarcane bagasse fermentation in the presence of 2 M NaCl that was set in the laboratory. This strain was identified by polyphasic criteria as Aspergillus caesiellus. The fungus showed
Michelle R Baker et al.
Biochemistry research international, 2011, 739712-739712 (2011-09-16)
Persistent alteration of protein conformation due to interaction with isoflurane may be a novel molecular aspect of preconditioning. We preincubated human serum albumin with isoflurane, dialyzed to release agent, and assessed protein conformation. Susceptibility to chemical modification by methylglyoxal and
Immunomodulatory, antiglycation and anti-ulcerative properties of Ruellia squarrosa Fenzl Acanthaceae
Afzal K, et al.
Tropical Journal of Pharmaceutical Research, 16(8), 1751-1755 (2017)
Beyond esterase-like activity of serum albumin. Histidine-(nitro) phenol radical formation in conversion cascade of p-nitrophenyl acetate and the role of infrared light
Kowacz M and Warszynski P
arXiv (2018)
Impact of diet on irinotecan toxicity in mice
Mallick P, et al.
Chemico-Biological Interactions, 291, 87-94 (2018)
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