P2658
Poly-L-lysine hydrochloride
suitable for cell culture, Mol wt 15,000-30,000
Synonym(s):
L-Lysine hydrochloride homopolymer
Product Name
Poly-L-lysine hydrochloride, mol wt 15,000-30,000
form
powder or solid
mol wt
15,000-30,000
technique(s)
cell culture | mammalian: suitable
color
white to light yellow
application(s)
cell analysis
storage temp.
−20°C
Quality Level
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Related Categories
Application
Poly-lysine with mol. wt. >70,000 is useful in promoting cell adhesion to solid substrates.
Poly-L-lysine hydrochloride has been used to coat glass slides and coverslips to facilitate cell attachment.
Analysis Note
Molecular weight based on viscosity.
Biochem/physiol Actions
L-Lysine is believed to prevent osteoporosis of bones, which is a characteristics of vascular calcification. Glutaric aciduria type I and pyridoxine-dependent epilepsy occurs due to lack of L-lysine catabolic pathway. Lysine participates in the regulation of NO (nitric oxide) synthesis. It possesses antiviral activity, therefore it is used in the treatment of Herpes simplex. L-Lysine is associated with a number of biochemical reactions such as acetylation, O-linked glycosylation, ubiquitination and protein methylation. Poly-L-lysine is considered as a biocompatible polymer and serves for the purpose of drug delivery across cell membrane. It is useful as one of the nanosized contrast agents in MRI (magnetic resonance imaging).
Other Notes
For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Archishman Ghosh et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(39), 19474-19483 (2019-09-12)
Membraneless organelles, corresponding to the droplet phase upon liquid-liquid phase separation (LLPS) of protein or protein-RNA mixtures, mediate myriad cellular functions. Cells use a variety of biochemical signals such as expression level and posttranslational modification to regulate droplet formation and
Primary culture of neural precursors from the ovine central nervous system (CNS)
A. H. Duitozz and T. Hevor
Journal of Neuroscience Methods, 131-140 (2001)
Multi-technique characterization of poly-L-lysine dendrigrafts-Cu(II) complexes for biocatalysis.
Rossi JC
Macromolecular Bioscience, 15(2), 275-290 (2015)
The role of signaling pathways on proliferation and self-renewal of cultured bovine primitive germ cells
Sahare Mahesh
Reproductive medicine and biology, 14(1) (2015)
Dietary l-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats
Akihiro Shimomura
Journal of the American Society of Nephrology, 25(9), 1954-1965 (2014)
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