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Merck

P3655

Poly-L-ornithine hydrobromide

Mol wt 30,000-70,000

Synonym(s):

L-Ornithine homopolymer hydrobromide

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About This Item

CAS Number:
UNSPSC Code:
12352209
NACRES:
NA.26
MDL number:
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Product Name

Poly-L-ornithine hydrobromide, mol wt 30,000-70,000

SMILES string

[Br-].NC(CCCN)C(=O)O.[H+]

InChI

1S/C5H12N2O2.BrH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H

InChI key

GWRQMKDBBHFVIZ-UHFFFAOYSA-N

form

powder

mol wt

30,000-70,000

color

white to off-white

storage temp.

−20°C

Quality Level

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Analysis Note

Molecular weight based on viscosity. Also assayed by MALLS.

Application

Poly-L-ornithine hydrobromide has been used to coat coverslips in culture vessels for culturing neural progenitor cells. It has also been used to coat culture plates for culturing cerebral cells of mice.

Biochem/physiol Actions

Poly-L-ornithine is a specialized coating that acts as a charge modifier. It is a polycationic synthetic amino acid polymer. It boosts nasal absorption of hydrophilic macromolecular drugs.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer
Yusuke Kamiya
Biologicals : Journal of the International Association of Biological Standardization (2017)
Isolation, characterization, and differentiation of multipotent neural
progenitor cells from human cerebrospinal fluid in fetal
cystic myelomeningocele
Mario Marotta
Stem Cell Research (2017)
FGF2 and Insulin Signaling Converge to Regulate Cyclin D Expression in Multipotent Neural Stem Cells
Adedamola Adepoju
Stem Cell Research (2013)
Elena Maria Boggio et al.
Molecular neurobiology, 56(9), 5987-5997 (2019-02-02)
Perineuronal nets (PNNs) are condensed structures in the extracellular matrix that mainly surround GABA-ergic parvalbumin-positive interneurons in the adult brain. Previous studies revealed a parallel between PNN formation and the closure of the critical period. Moreover, ocular dominance plasticity is
S K Tam et al.
Acta biomaterialia, 7(4), 1683-1692 (2010-12-15)
There is a need for better understanding of the biocompatibility of alginate-polycation microcapsules based on their physicochemical characteristics. Microcapsules composed of alginate with 44% (IntG) or 71% (HiG) guluronate, gelled with calcium (Ca) or barium (Ba) and coated with poly-L-lysine

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