Product Name
Poly-L-ornithine hydrobromide, mol wt 30,000-70,000
SMILES string
[Br-].NC(CCCN)C(=O)O.[H+]
InChI
1S/C5H12N2O2.BrH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H
InChI key
GWRQMKDBBHFVIZ-UHFFFAOYSA-N
form
powder
mol wt
30,000-70,000
color
white to off-white
storage temp.
−20°C
Quality Level
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Analysis Note
Molecular weight based on viscosity. Also assayed by MALLS.
Application
Poly-L-ornithine hydrobromide has been used to coat coverslips in culture vessels for culturing neural progenitor cells. It has also been used to coat culture plates for culturing cerebral cells of mice.
Biochem/physiol Actions
Poly-L-ornithine is a specialized coating that acts as a charge modifier. It is a polycationic synthetic amino acid polymer. It boosts nasal absorption of hydrophilic macromolecular drugs.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer
Yusuke Kamiya
Biologicals : Journal of the International Association of Biological Standardization (2017)
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progenitor cells from human cerebrospinal fluid in fetal
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Mario Marotta
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Adedamola Adepoju
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Elena Maria Boggio et al.
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Perineuronal nets (PNNs) are condensed structures in the extracellular matrix that mainly surround GABA-ergic parvalbumin-positive interneurons in the adult brain. Previous studies revealed a parallel between PNN formation and the closure of the critical period. Moreover, ocular dominance plasticity is
S K Tam et al.
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