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Merck

SML2984

BIX02188

≥98% (HPLC)

Synonym(s):

(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-Indole-6-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C25H24N4O2
CAS Number:
334949-59-6
Molecular Weight:
412.48
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD18157583
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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form

powder

SMILES string

N1c2c(ccc(c2)C(=O)N)\C(=C(\Nc4cc(ccc4)CN(C)C)/c3ccccc3)\C1=O

InChI

1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)/b23-22-

InChI key

FSZPIAXLCCQFCM-FCQUAONHSA-N

assay

≥98% (HPLC)

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

BIX02188 is a potent and selective inhibitor of MEK5 with IC50 of 4.3 nM. BIX02188 also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
Selective MEK5 Inhibitor; inhibitor of MEK5/ERK5 signaling.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Yutaro Obara et al.
Molecular pharmacology, 77(1), 10-16 (2009-10-28)
Extracellular signal-regulated kinases (ERKs) or mitogen-activated protein kinases (MAPKs) are involved in cellular proliferation, differentiation, migration, and gene expression. The MAPK family includes ERK1/2, c-Jun NH(2)-terminal kinases 1, 2, and 3, p38MAPK alpha, beta, gamma, and -delta, and ERK5 as

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