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Merck

907197

1,4-Dinitro-1-imidazole

Synonym(s):

1,4-DNIm, 1,4-Dinitroimidazole, Bifunctional bioconjugation reagent

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About This Item

Empirical Formula (Hill Notation):
C3H2N4O4
CAS Number:
Molecular Weight:
158.07
UNSPSC Code:
12352005
MDL number:
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assay

≥95%

form

solid

storage temp.

−20°C

InChI

1S/C3H2N4O4/c8-6(9)3-1-5(2-4-3)7(10)11/h1-2H

InChI key

HZPSREFSUPXCMN-UHFFFAOYSA-N

Application

1,4-Dinitro-1-imidazole (1,4-DNIm) and other dinitroimidazoles were demonstrated to be bifunctional bioconjugation reagents for protein functionalization and peptide macrocyclization. In acidic to neutral aqueous conditions, 1,4-DNIms chemoselectively react with cysteines; in organic solvents in the presence of base, 1,4-DNIms chemoselectively react with lysines to form stable conjugates


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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