C5490
C75
≥98% (HPLC), fatty acid synthase (FAS) inhibitor of, powder
Synonym(s):
4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C14H22O4
CAS Number:
Molecular Weight:
254.32
UNSPSC Code:
41121801
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
C75, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear
storage temp.
2-8°C
SMILES string
CCCCCCCCC1OC(=O)C(=C)C1C(O)=O
InChI
1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)
InChI key
VCWLZDVWHQVAJU-UHFFFAOYSA-N
Application
C75 has been used:
- as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin
- as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)
- as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide
Biochem/physiol Actions
C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.
C75 helps to increase the cancer‐killing capability of ionizing radiation.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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