F5386
Fibrin from human plasma
insoluble powder
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About This Item
Form:
powder
Biological source:
human plasma
SMILES string
N(CC(=O)NC)C(=O)CN
InChI key
BWGVNKXGVNDBDI-UHFFFAOYSA-N
InChI
1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)
biological source
human plasma
form
powder
technique(s)
indirect ELISA: suitable
Quality Level
General description
Fibrin is produced from cross-linking of fibrinogen by thrombin. Fibrinogen is made up of two monomers each containing three polypeptide chains. Fibrinogen is a major plasma protein.
Application
Fibrin from human plasma has been used:
- for in vitro cleavage of fibrinogen and fibrin
- as a reference for true component analysis (TCA) and principal component analysis (PCA) of Raman spectra
- as a reference in Raman spectroscopy to study the binding mechanisms and the binding efficiency of the different polyoxometalates (POMs)
Biochem/physiol Actions
Fibrin acts as an important bio-polymer in the primary blood clotting process. It creates a scaffold for infiltrating cells during tissue repair. Fibrin is widely used as a tissue sealant for tissue regeneration applications as it enables the formation of a biocompatible physical structure. It is also used in delivery systems for cells and bioactive molecules. The fibrin matrix resembles the native pancreas and can serve as a scaffold material for islet transplantation. Fibrin has been used in studies to obtain fibrin-specific monoclonal antibodies (mAbs). These mAbs may be used to determine their role in fibrin polymerization and use in fibrin quantification in blood plasma.
Preparation Note
Prepared by clotting fibrinogen to yield a crosslinked fibrin
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Weimin Wu et al.
The Journal of investigative dermatology, 134(1), 256-263 (2013-07-24)
Dermatopontin (DP) is a small extracellular matrix component in the dermis. Fibrin is a major component of a provisional matrix that is formed just after wounding. Previously, we found that DP was present in the provisional matrix, and it interacted
Abraham R Alfonso et al.
Acta biomaterialia, 9(9), 8149-8157 (2013-06-26)
Tissue engineered heart valves (TEHVs) may provide a permanent solution to congenital heart valve disease by permitting somatic valve growth in the pediatric patient. However, to date, TEHV studies have focused primarily on collagen, the dominant component of valve extracellular
James C Fredenburgh et al.
The Journal of biological chemistry, 288(41), 29394-29402 (2013-08-31)
The nonspecific binding of heparin to plasma proteins compromises its anticoagulant activity by reducing the amount of heparin available to bind antithrombin. In addition, interaction of heparin with fibrin promotes formation of a ternary heparin-thrombin-fibrin complex that protects fibrin-bound thrombin
Kristen T Morin et al.
Experimental cell research, 319(16), 2409-2417 (2013-06-27)
In vitro models of endothelial assembly into microvessels are useful for the study of angiogenesis and vasculogenesis. In addition, such models may be used to provide the microvasculature required to sustain engineered tissues. A large range of in vitro models
Matteo Centola et al.
Tissue engineering. Part A, 19(17-18), 1960-1971 (2013-04-25)
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