Normal Human Intrahepatic Biliary Epithelial Cells (Cholangioctyes)

Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details. Primary human Cholangiocytes, also known as human intrahepatic biliary epithelial cells, are epithelial cells that line the intrahepatic bile ducts. Chonlangiocytes are important for ductal bile modification and are targeted in multiple liver diseases, such as primary biliary cirrhosis, cholangiocarcinoma and sclerosing cholangitis.

Human cholangiocytes are ideal in studies of: toxicity, bile production and absorption, bile duct fibrosis, hormone signaling, cholangitis, cholangiocarcinoma and more. We offer matched sets of cholangiocytes cells from same donor as Hepatocytes, which can be used for co-culture systems to better simulate the complex microenvironment of the liver and gain insights into various liver-related diseases and conditions.

Our cryopreserved human Cholangiocytes cells are derived from the human liver, with each donor providing documented consent for research use of non-transplantable organs or tissues. Following the primary culture, these cells are cryopreserved. Each lot undergoes testing for specific cell markers and comes with a guarantee of ≥ 70% post-thaw viability. In addition, all cells have been tested for the absence of HIV, HBV, HCV, Syphillis and microbial contaminants (fungi, bacteria, and mycoplasma).

Each donor is tested and found non-reactive to viral DNA from HIV-1, HIV-2, HTLV I, HTLV II, hepatitis B and hepatitis C. However, no known test can offer complete assurance that the viruses that cause HIV-1, HIV-2, HTLV I, HTLV II, hepatitis B and hepatitis C are not present. Proper precautions and biological containment should be taken when handling cells of human origin, due to their potential biohazardous nature. All human based products should be handled at a BSL-2 (Biosafety Level 2) or higher.