O1641
Ovalbumin (323-339) (chicken, Japanese quail)
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About This Item
NACRES:
NA.26
UNSPSC Code:
12352202
assay
97-100% (HPLC)
Quality Level
form
lyophilized powder
composition
peptide content, 65-100%
color
white
solubility
water, double-distilled: soluble
storage temp.
−20°C
General description
The peptide is a major MHC class II-restricted T-cell epitope of Ovalbumin which is used for studies of immunological allergic responses such as asthma, food allergy and more..
Ovalbumin (323-339) is an egg white protein surrounded by B-cell epitopes, which are bound by specific IgE antibodies. In addition to this, it also contains CD4+ T cell epitopes.
Application
Ovalbumin (323-339) (chicken, Japanese quail) has been used to induce allergic asthma in mice.
Biochem/physiol Actions
Ovalbumin (OVA) peptide 323-339 mediates 25–35% of T-cell response to intact OVA in isolated BALB/c mouse. OVA 323-339 has been widely used to determine the characteristics of class II major histocompatibility complex (MHC)-peptide binding and T-cell activation.
With the help of two functionally distinct registers ovalbumin (323-339) peptide can bind to histocompatibility complex class II I-A(d) protein.
Physical form
Lyophilized from 0.1% aqueous TFA
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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ORMDL3 may participate in the pathogenesis of bronchial xn-epithelialmesenchymal-1e9l transition in asthmatic mice with airway remodeling
Cheng Q, et al.
Molecular Medicine Reports, 17(1), 995-1005 (2018)
Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers
McFarland BJ, et al.
Biochemistry, 38(50), 16663-16670 (1999)
Weifang Wang et al.
Frontiers in nutrition, 9, 931427-931427 (2022-08-02)
Asthma is a chronic disease, which is harmful to the health of the body and the quality of life. Supplementation of Lactobacillus can affect the immune environment of the lungs through the gut-lung axis. This study aimed to explore the